Pathogenic Yersinia DNA in intestinal specimens of pediatric patients with Crohn's disease.

Abstract

Studies indicate a close relationship between Yersinia and Crohn's disease in adults. Our study tested 77 colonic specimens from children with Crohn's disease for the presence of Yersinia DNA using a validated polymerase chain reaction (PCR) assay. Control cases included specimens from 45 ulcerative colitis patients and 10 appendicitis patients. The presence of Yersinia in Crohn's specimens was significant compared to the control specimens (9% vs. 0%; p = 0.0055). While our study supports the medical literature, future studies are needed to determine if the relationship between Crohn's disease and Yersinia is an initiating or mediating factor in the pathogenesis of pediatric Crohn's disease.

• Authors: Sarah B Leu, Sarah Catherine Shulman, Charlotte Katherine Steelman, Laura W Lamps, Ozlem P Bulut, Carlos R Abramowsky, Benjamin D Gold, Sarah Szlam, Christina Stockwell, Jennifer Havens, Soha Kolta, Bahig M Shehata
• Journal: Fetal and pediatric pathology (Fetal Pediatr Pathol) Vol. 32 Issue 5 Pg. 367-70 (Oct 2013) ISSN: 1551-3823 [Electronic] England
• PMID: 23611062 (Publication Type: Journal Article)

Chemical References

• Bacterial Proteins
• DNA, Bacterial
• YopP protein, Yersinia

Topics

• Adolescent
• Bacterial Proteins (genetics)
• Case-Control Studies
• Child
• Crohn Disease (microbiology)
• DNA, Bacterial (genetics, isolation & purification)
• Female
• Genes, Bacterial
• Humans
• Intestinal Mucosa (microbiology)
• Male
• Retrospective Studies
• Yersinia (genetics, isolation & purification, pathogenicity)
• Yersinia enterocolitica (genetics, isolation & purification, pathogenicity)
• Yersinia pseudotuberculosis (genetics, isolation & purification, pathogenicity)
• Young Adult