Abstract |
Epidermodysplasia verruciformis (EV) is a rare heritable skin disease that results in unusual susceptibility to infection with specific types of human papillomavirus (HPV). Here we report a 53-year-old man with EV who developed Bowen's disease on his lower eyelid and the chest. Mutation analysis of EVER1 gene revealed homozygous splice acceptor site mutation (IVS8-2, A > T). In this patient, HPV3, HPV14, and HPV38 had been identified from the skin lesions. The Bowen's skin lesion on the left lower eye-lid was treated by photodynamic therapy ( PDT) using 5-aminolevulinic acid (ALA) and pulsed dye laser (PDL). After two rounds of the PDT treatment, the skin lesion disappeared and a skin biopsy confirmed the efficacy of the treatment. This method was simple, less invasive than other treatments, and achieved a satisfactory cosmetic result.
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Authors | Mari Sunohara, Toshiyuki Ozawa, Kuniyuki Morimoto, Teruichi Harada, Masamitsu Ishii, Kazuyoshi Fukai |
Journal | Osaka city medical journal
(Osaka City Med J)
Vol. 58
Issue 2
Pg. 77-82
(Dec 2012)
ISSN: 0030-6096 [Print] Japan |
PMID | 23610850
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Membrane Proteins
- Photosensitizing Agents
- TMC6 protein, human
- TMC8 protein, human
- Aminolevulinic Acid
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Topics |
- Aminolevulinic Acid
(therapeutic use)
- Biopsy
- Bowen's Disease
(drug therapy, pathology, virology)
- Epidermodysplasia Verruciformis
(complications, genetics, virology)
- Eyelid Neoplasms
(drug therapy, pathology, virology)
- Humans
- Lasers, Dye
- Male
- Membrane Proteins
(genetics)
- Middle Aged
- Mutation
- Photochemotherapy
(instrumentation)
- Photosensitizing Agents
(therapeutic use)
- Skin Neoplasms
(drug therapy, pathology, virology)
- Treatment Outcome
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