Abstract | AIMS: METHODS AND RESULTS: We prospectively analysed 124 patients with various types of Fontan surgery between October 2006 and February 2011. We included 49 patients with older Fontan modification [atriopulmonary connection (APC) and atrioventricular connection (AVC)] and 75 patients with total cavopulmonary connection (TCPC). The NT-proBNP levels of patients with APC/AVC were significantly higher than in patients with TCPC (P < 0.001), even after accounting for sex, age, ventricular function, atrioventricular regurgitation, ventricular morphology, and arrhythmia (P = 0.035). Levels of NT-proBNP positively correlated with atrioventricular valve regurgitation (r = 0.29, P = 0.013) and ventricular dysfunction (r = 0.23, P = 0.052) only in patients with TCPC, but not in patients with APC or AVC (r = 0.01, P = 0.509 and r = 0.10, P = 0.493, respectively). CONCLUSION: Levels of NT-pro BNP are related to the type of Fontan circulation. The older types (APC/AVC) that involve more atrial tissue in the systemic venous pathway show higher NT-proBNP levels independently of their cardiac status. Their NT-proBNP levels should be interpreted with care.
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Authors | Pinar Bambul Heck, Jan Müller, Ruth Weber, Alfred Hager |
Journal | European journal of heart failure
(Eur J Heart Fail)
Vol. 15
Issue 6
Pg. 644-9
(Jun 2013)
ISSN: 1879-0844 [Electronic] England |
PMID | 23610138
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Adolescent
- Adult
- Biomarkers
(blood)
- Child
- Echocardiography
- Female
- Follow-Up Studies
- Fontan Procedure
(methods)
- Heart Defects, Congenital
(blood, surgery)
- Heart Valves
(physiopathology)
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Prospective Studies
- Ventricular Function
- Young Adult
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