Abstract | INTRODUCTION: METHODS: RESULTS: A total of 6 RCTs (n = 390 patients) were included; the mean methodological score of all trials was 10 (range, 6-13). When the results of these studies were aggregated, FO-containing emulsions were associated with a trend toward a reduction in mortality (risk ratio [RR], 0.71; 95% confidence interval [CI], 0.49-1.04; P = .08; heterogeneity I (2) = 0%) and a reduction in the duration of mechanical ventilation (weighted mean difference in days [WMD], -1.41; 95% CI, -3.43 to 0.61; P = .17). However, this strategy had no effect on infections (RR, 0.76; 95% CI, 0.42-1.36; P = .35) and intensive care unit length of stay (WMD, -0.46; 95% CI, -4.87 to 3.95; P = .84, heterogeneity I (2) = 75%). CONCLUSION: FO-containing lipid emulsions may be able to decrease mortality and ventilation days in the critically ill. However, because of the paucity of clinical data, there is inadequate evidence to recommend the routine use of parenteral FO. Large, rigorously designed RCTs are required to elucidate the efficacy of parenteral FO in the critically ill.
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Authors | William Manzanares, Rupinder Dhaliwal, Brian Jurewitsch, Renee D Stapleton, Khursheed N Jeejeebhoy, Daren K Heyland |
Journal | JPEN. Journal of parenteral and enteral nutrition
(JPEN J Parenter Enteral Nutr)
Vol. 38
Issue 1
Pg. 20-8
(Jan 2014)
ISSN: 1941-2444 [Electronic] United States |
PMID | 23609773
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Chemical References |
- Emulsions
- Fatty Acids, Omega-3
- Fish Oils
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Topics |
- Critical Illness
(therapy)
- Emulsions
(chemistry)
- Enteral Nutrition
(methods)
- Fatty Acids, Omega-3
(administration & dosage)
- Fish Oils
(administration & dosage)
- Humans
- Intensive Care Units
- Length of Stay
- Parenteral Nutrition
(methods)
- Randomized Controlled Trials as Topic
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