Abstract | BACKGROUND AND OBJECTIVES:
Polycystic ovary syndrome (PCOS) is a common problem in women at fertile age. A prospective study was conducted to clarify the pathophysiological responses during an application of insulin sensitizer, metformin and weight reduction therapy at the Gynecology Center in Ohud hospital, in AL-Madinah AL-Munawarah, Kingdom of Saudi Arabia. METHODOLOGY: Twenty healthy women served as controls and 180 PCOS women divided into three groups participated in the study. First group was treated with Clomid citrate 100mg/day from the 2nd day of menses to the 6th day plus gonadotrophin from day three to the 13th. Group II was treated as group I plus 850mg metformin twice a day and group III was treated as group I plus weight reduction. Clinical symptoms, menstrual pattern, hirsutism, blood glucose, body mass index, waist-to-hip ratio, insulin, hormonal, and lipid profiles were assessed pre- and post treatment. Insulin resistance was calculated. RESULTS: CONCLUSION:
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Authors | Omar Al-Nozha, Fawziah Habib, Moaz Mojaddidi, Mohamed Fath El-Bab |
Journal | Pathophysiology : the official journal of the International Society for Pathophysiology
(Pathophysiology)
Vol. 20
Issue 2
Pg. 131-7
(Apr 2013)
ISSN: 0928-4680 [Print] Switzerland |
PMID | 23608322
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |