Autologous muscle-derived cells for the treatment of female stress urinary incontinence: a 2-year follow-up of a Polish investigation.

Abstract

AIMS:

We evaluated the safety, feasibility and initial effects of therapy with muscle-derived cells (MDCs) for women with stress urinary incontinence (SUI).

METHODS:

MDCs were isolated from an upper-arm muscle biopsy from 16 women with SUI. Cells were isolated by enzymatic digestion and expanded in vitro for 8-10 weeks. A quantity of 0.6-25 × 10(6) of the obtained cells were injected transurethrally into the urethral rhabdosphincter of women under local anesthesia. The cells were placed circumferentially at the 9, 12, and 3 O'clock positions with endoscopic guidance.

RESULTS:

The initial results of the treatment of SUI with adult muscle-derived stem cells demonstrate the safety and feasibility of using these cells. The 2-year follow-up revealed a 75% success rate, with some patients achieving complete improvement (50%) and some patients achieving partial improvement (25%), suggesting that the prospects for this method are encouraging.

CONCLUSIONS:

Stem cell therapy promises to become a minimally invasive method for the regeneration of the urethral rhabdosphincter muscle. Injecting a small number of cells does not preclude obtaining the desired therapeutic result.

• Authors: Klaudia Stangel-Wojcikiewicz, Danuta Jarocha, Monika Piwowar, Robert Jach, Tadeusz Uhl, Antoni Basta, Marcin Majka
• Journal: Neurourology and urodynamics (Neurourol Urodyn) Vol. 33 Issue 3 Pg. 324-30 (Mar 2014) ISSN: 1520-6777 [Electronic] United States
• PMID: 23606303 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2013 Wiley Periodicals, Inc.

Topics

• Autografts
• Cells, Cultured
• Endoscopy
• Feasibility Studies
• Female
• Humans
• Middle Aged
• Muscle, Skeletal (cytology, transplantation)
• Poland
• Recovery of Function
• Regeneration
• Stem Cell Transplantation (adverse effects, methods)
• Time Factors
• Treatment Outcome
• Upper Extremity
• Urethra (physiopathology)
• Urinary Bladder (physiopathology)
• Urinary Incontinence, Stress (diagnosis, physiopathology, therapy)
• Urodynamics