Abstract | BACKGROUND:
Corticosteroids are widely used in pediatric open-heart surgery to reduce systemic inflammatory response and to mediate possible cardioprotective effects. However, the optimal dosing of corticosteroids is unknown and their administration varies considerably between different institutions. METHODS: RESULTS: CONCLUSIONS: Intravenous 30 mg/kg methylprednisolone administered before cardiopulmonary bypass resulted in high effective plasma drug concentrations and a decreased inflammatory response. However, no cardioprotective effect or better clinical outcome was noticed.
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Authors | Juho Keski-Nisula, Eero Pesonen, Klaus T Olkkola, Kaija Peltola, Pertti J Neuvonen, Netta Tuominen, Heikki Sairanen, Sture Andersson, Pertti K Suominen |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 95
Issue 6
Pg. 2126-32
(Jun 2013)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 23602068
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Blood Glucose
- Interleukins
- Methylprednisolone
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Topics |
- Blood Glucose
(analysis, drug effects)
- Cardiac Surgical Procedures
(adverse effects, methods, mortality)
- Cardiopulmonary Bypass
(adverse effects, methods)
- Double-Blind Method
- Female
- Follow-Up Studies
- Heart Defects, Congenital
(diagnosis, mortality, surgery)
- Hospital Mortality
(trends)
- Humans
- Infant, Newborn
- Inflammation
(prevention & control)
- Infusions, Intravenous
- Interleukins
(blood, metabolism)
- Male
- Methylprednisolone
(administration & dosage, adverse effects)
- Postoperative Complications
(prevention & control)
- Preoperative Care
(methods)
- Reference Values
- Risk Assessment
- Sensitivity and Specificity
- Survival Rate
- Treatment Outcome
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