Abstract | BACKGROUND: MATERIALS AND METHODS: For this study, 94 perennial allergic rhinitis patients aged 6-12 years were randomly assigned to two treatment groups: an MFM group and an FP group. Treatment was provided for 4 weeks. The effects of the two agents were compared using the Pediatric Rhinoconjunctivitis Quality of Life Questionnaire and total symptom scores (TSSs). Nasal-peak expiratory flow rates and eosinophil percentage in nasal smears were also compared between the two groups. RESULTS: Patients in the MFM group exhibited significant improvement in their TSS (t = -2.65, p < 0.05). A detailed TSS analysis showed MFM to be more effective for relieving nasal symptoms, whereas FP was more effective for relieving non-nasal symptoms. Patient questionnaire scores suggested a significant reduction in symptoms for both the MFM (t = -7.23, p < 0.01) and FP (t = -5.43, p < 0.01) groups. The flow rate test results indicated significant improvements in the MFM group (t = 2.27, p < 0.05). CONCLUSION: Following the 4-week therapy, MFM provided greater improvement compared to FP for symptoms of childhood perennial-allergic rhinitis. Based on their TSSs, the MFM group experienced more effective relief of nasal symptoms, whereas the FP group experienced more effective relief of non-nasal symptoms.
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Authors | Ka-Kit Mak, Min-Sho Ku, Ko-Hsiu Lu, Hai-Lun Sun, Ko-Huang Lue |
Journal | Pediatrics and neonatology
(Pediatr Neonatol)
Vol. 54
Issue 4
Pg. 239-45
(Aug 2013)
ISSN: 2212-1692 [Electronic] Singapore |
PMID | 23597528
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2013. Published by Elsevier B.V. |
Chemical References |
- Allergens
- Androstadienes
- Anti-Allergic Agents
- Dust
- Nasal Sprays
- Pregnadienediols
- Mometasone Furoate
- Fluticasone
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Topics |
- Allergens
- Androstadienes
(administration & dosage)
- Animals
- Anti-Allergic Agents
(administration & dosage)
- Child
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Dust
(immunology)
- Female
- Fluticasone
- Follow-Up Studies
- Humans
- Male
- Mites
(immunology)
- Mometasone Furoate
- Nasal Sprays
- Patient Satisfaction
(statistics & numerical data)
- Pregnadienediols
(administration & dosage)
- Prospective Studies
- Quality of Life
- Rhinitis, Allergic, Perennial
(diagnosis, drug therapy, immunology)
- Risk Assessment
- Severity of Illness Index
- Treatment Outcome
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