Results of 226 patients with T3 laryngeal carcinoma after treatment with transoral laser microsurgery.

Abstract

BACKGROUND:

The purpose of this study was to assess the feasibility of transoral laser microsurgery (TLM) in treatment of pT3 laryngeal cancer.

METHODS:

We conducted a retrospective case series study of 226 patients with pT3 glottic (n = 122; 54%) or supraglottic laryngeal carcinoma (n = 104; 46%). All patients were treated by TLM in combination with neck dissection (63%) and with postoperative radiotherapy (18%). Our main outcome measures were local control, organ preservation, functional outcome, overall survival, recurrence-free survival, and disease-specific survival.

RESULTS:

Median follow-up period was 57.8 months. The 5-year organ-preservation and local control rates for all patients were 87% and 71.4%, respectively. The 5-year overall, recurrence-free, and disease-specific survival were 64.4%, 63.0%, and 83.3%, respectively.

CONCLUSION:

Results are comparable to partial or total laryngectomy, while being superior to primary chemo(radio)therapy. TLM results in low morbidity, rapid recovery, and good function and can be a valid option for organ-preserving surgery of pT3 glottic and supraglottic cancer.

• Authors: Martin Canis, Friedrich Ihler, Alexios Martin, Hendrik A Wolff, Christoph Matthias, Wolfgang Steiner
• Journal: Head & neck (Head Neck) Vol. 36 Issue 5 Pg. 652-9 (May 2014) ISSN: 1097-0347 [Electronic] United States
• PMID: 23596018 (Publication Type: Comparative Study, Evaluation Study, Journal Article)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Topics

• Adult
• Aged
• Carcinoma, Squamous Cell (mortality, pathology, surgery, therapy)
• Chemoradiotherapy (methods)
• Disease-Free Survival
• Feasibility Studies
• Female
• Glottis (pathology, surgery)
• Humans
• Kaplan-Meier Estimate
• Laryngeal Neoplasms (mortality, pathology, surgery, therapy)
• Laryngectomy (methods)
• Laser Therapy (methods)
• Male
• Microsurgery (methods)
• Middle Aged
• Minimally Invasive Surgical Procedures (methods, mortality)
• Neck Dissection (methods)
• Neoplasm Invasiveness (pathology)
• Neoplasm Recurrence, Local (mortality, pathology, surgery)
• Neoplasm Staging
• Organ Sparing Treatments
• Prognosis
• Proportional Hazards Models
• Retrospective Studies
• Risk Assessment
• Survival Rate
• Treatment Outcome