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[Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid plus mannitol in knee osteoarthritis over a 6-month period].

AbstractOBJECTIVE:
To evaluate the safety and efficacy of a single intra-articular injection of 2% hyaluronic acid (HA)+mannitol in symptomatic knee osteoarthritis (KOA).
MATERIAL AND METHODS:
Pilot, multicentre, open, non-comparative study performed in eighty patients with painful KOA, of whom 79 completed the study. They received one injection of 2ml of 2% HA+0.5% mannitol (Day 0) and were followed-up for 6 months. On Days 0, 15, 30, 60, 90, 120, 150 and 180, pain and joint function were assessed using a visual analogue scale (VAS) and WOMAC index. Efficacy and safety by investigator and patient, and rescue medication, as an indirect measure of pain, were also recorded.
RESULTS:
A significant reduction in joint pain, stiffness and functional disability compared with baseline was observed at every follow-up visit (P<.001). Joint function improved by 38.7% on Day 30, reaching 47.5% on Day 180. Rescue medication use decreased from 58.2% at baseline to 2.5% on Day 90, increasing in the last visits. Efficacy and safety were positively evaluated by investigators and patients. No serious adverse events were observed. Mild side effects were reported in 4 patients (local pain and swelling in the infiltration area).
DISCUSSION:
There is evidence that repeated intra-articular injections of HA improve symptoms in KOA. However, studies with a single injection of HA have shown mixed results. This study demonstrates that one single intra-articular injection of non-cross-linked HA reduces joint pain and increases function in patients with KOA over a period of at least 6 months.
AuthorsA Borrás-Verdera, V Calcedo-Bernal, J Ojeda-Levenfeld, C Clavel-Sainz
JournalRevista española de cirugía ortopédica y traumatología (Rev Esp Cir Ortop Traumatol) 2012 Jul-Aug Vol. 56 Issue 4 Pg. 274-80 ISSN: 1988-8856 [Electronic] Spain
Vernacular TitleEficacia y seguridad de una única inyección intraarticular de ácido hialurónico al 2% más manitol en artrosis de rodilla durante un periodo de 6 meses.
PMID23594845 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
CopyrightCopyright © 2011 SECOT. Published by Elsevier España, S.L. All rights reserved.
Chemical References
  • Viscosupplements
  • Mannitol
  • Hyaluronic Acid
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Drug Administration Schedule
  • Drug Therapy, Combination
  • Follow-Up Studies
  • Humans
  • Hyaluronic Acid (administration & dosage, therapeutic use)
  • Mannitol (administration & dosage, therapeutic use)
  • Middle Aged
  • Osteoarthritis, Knee (drug therapy)
  • Pilot Projects
  • Prospective Studies
  • Treatment Outcome
  • Viscosupplementation (methods)
  • Viscosupplements (administration & dosage, therapeutic use)

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