[Efficacy and safety of a single intra-articular injection of 2% hyaluronic acid plus mannitol in knee osteoarthritis over a 6-month period].

Abstract

OBJECTIVE:

To evaluate the safety and efficacy of a single intra-articular injection of 2% hyaluronic acid (HA)+mannitol in symptomatic knee osteoarthritis (KOA).

MATERIAL AND METHODS:

Pilot, multicentre, open, non-comparative study performed in eighty patients with painful KOA, of whom 79 completed the study. They received one injection of 2ml of 2% HA+0.5% mannitol (Day 0) and were followed-up for 6 months. On Days 0, 15, 30, 60, 90, 120, 150 and 180, pain and joint function were assessed using a visual analogue scale (VAS) and WOMAC index. Efficacy and safety by investigator and patient, and rescue medication, as an indirect measure of pain, were also recorded.

RESULTS:

A significant reduction in joint pain, stiffness and functional disability compared with baseline was observed at every follow-up visit (P<.001). Joint function improved by 38.7% on Day 30, reaching 47.5% on Day 180. Rescue medication use decreased from 58.2% at baseline to 2.5% on Day 90, increasing in the last visits. Efficacy and safety were positively evaluated by investigators and patients. No serious adverse events were observed. Mild side effects were reported in 4 patients (local pain and swelling in the infiltration area).

DISCUSSION:

There is evidence that repeated intra-articular injections of HA improve symptoms in KOA. However, studies with a single injection of HA have shown mixed results. This study demonstrates that one single intra-articular injection of non-cross-linked HA reduces joint pain and increases function in patients with KOA over a period of at least 6 months.

• Authors: A Borrás-Verdera, V Calcedo-Bernal, J Ojeda-Levenfeld, C Clavel-Sainz
• Journal: Revista espanola de cirugia ortopedica y traumatologia (Rev Esp Cir Ortop Traumatol) 2012 Jul-Aug Vol. 56 Issue 4 Pg. 274-80 ISSN: 1988-8856 [Electronic] Spain
• Vernacular Title: Eficacia y seguridad de una única inyección intraarticular de ácido hialurónico al 2% más manitol en artrosis de rodilla durante un periodo de 6 meses.
• PMID: 23594845 (Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study)
• Copyright: Copyright © 2011 SECOT. Published by Elsevier España, S.L. All rights reserved.

Chemical References

• Viscosupplements
• Mannitol
• Hyaluronic Acid

Topics

• Adult
• Aged
• Aged, 80 and over
• Drug Administration Schedule
• Drug Therapy, Combination
• Follow-Up Studies
• Humans
• Hyaluronic Acid (administration & dosage, therapeutic use)
• Mannitol (administration & dosage, therapeutic use)
• Middle Aged
• Osteoarthritis, Knee (drug therapy)
• Pilot Projects
• Prospective Studies
• Treatment Outcome
• Viscosupplementation (methods)
• Viscosupplements (administration & dosage, therapeutic use)