[Efficacy and safety of levofloxacin to non-gonorrheal urethritis].

Abstract

We investigated the efficacy and safety of levofloxacin (LVFX) 500mg once a day in patients with non-gonorrheal urethritis. Men, aged 20 years or older, with urethritis symptoms, and detection of Chlamydia trachomatis (C. trachomatis) or Mycoplasma genitalium (M. genitalium) by a microbiological examination were eligible for this study. Patients were administered LVFX 500mg, orally, once a day and the dosage period was seven days. We assumed 22 patients for a safety and efficacy analysis. In 22 patients, 17 patients had urethritis with C. trachomatis, 4 patients urethritis with M. genitalium, and one patient mixed infection of C. trachomatis and M. genitalium. In the clinial study, the primary endpoint was set as the bacteriological eradication rate at two to four weeks after completion of treatment. The bacterial eradication rate in the urethritis was 86.4% (19/22). The bacterial eradication rate in the urethritis with C. trachomatis, M. genitalium, and mixed infection of C. trachomatis and M. genitalium were 94.1% (16/17), 50.0% (2/4), 100% (1/1), respectively. A significant difference was not recognized among the three groups. The clinical efficacy at two to four weeks after completion of treatment was 90.9% (20/22). The clinical efficacy rates in the urethritis with C. trachomatis, M. genitalium, and mixed infection of C. trachomatis and M. genitalium were 100% (17/17), 50.0% (2/4), 100% (1/1), respectively. The efficacy rate of urethritis with M. genitalium was significantly low. No adverse drug reactions were observed. These results suggest that once-a-day levofloxacin (500mg) is effective and safe treatment for non-gonorrheal urethritis.

• Authors: Shoichi Onodera, Yasuhiko Onoe, Takahide Hosobe, Tetsuro Kato, Masaki Yoshida
• Journal: The Japanese journal of antibiotics (Jpn J Antibiot) Vol. 65 Issue 6 Pg. 399-409 (Dec 2012) ISSN: 0368-2781 [Print] Japan
• PMID: 23593735 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Levofloxacin
• Ofloxacin

Topics

• Adult
• Anti-Bacterial Agents (therapeutic use)
• Chlamydia Infections (drug therapy)
• Chlamydia trachomatis
• Humans
• Levofloxacin
• Male
• Middle Aged
• Mycoplasma Infections (drug therapy)
• Mycoplasma genitalium
• Ofloxacin (adverse effects, therapeutic use)
• Urethritis (drug therapy)