Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma.

Abstract

BACKGROUND:

Cytokeratin 7 (CK7) and Cam 5.2 are often used to differentiate extramammary Paget's disease (EPD) from squamous cell carcinoma (SCC) in situ because they are generally considered to be expressed in the former but not in the latter. However, we have encountered CK7+ and Cam 5.2+ SCCs.

METHODS:

We evaluated CK7, Cam 5.2 and Ber-Ep4 expression in SCC and EPD.

RESULTS:

We found significant CK7 and Cam 5.2 positivity in SCCs, particularly in those with a pagetoid pattern. Only one case expressed Ber-Ep4.

CONCLUSIONS:

We conclude that CK7 and Cam 5.2 expression may occur in SCC. A panel including Ber-Ep4 is advisable for immunohistochemical differentiation of EPD from SCC.

• Authors: Loren E Clarke, Andrea B Conway, Nicole M Warner, Patricia N Barnwell, Jennifer Sceppa, Klaus F Helm
• Journal: Journal of cutaneous pathology (J Cutan Pathol) Vol. 40 Issue 7 Pg. 646-50 (Jul 2013) ISSN: 1600-0560 [Electronic] United States
• PMID: 23590728 (Publication Type: Clinical Trial, Journal Article)
• Copyright: © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers
• Biomarkers, Tumor
• CAM 5.2 antigen
• Keratin-7
• Neoplasm Proteins
• human epithelial antigen-125
• Keratins

Topics

• Biomarkers
• Biomarkers, Tumor (biosynthesis)
• Carcinoma, Squamous Cell (metabolism, pathology)
• Female
• Gene Expression Regulation
• Humans
• Keratin-7 (biosynthesis)
• Keratins (biosynthesis)
• Male
• Neoplasm Proteins (biosynthesis)
• Skin Neoplasms (metabolism, pathology)