Abstract | BACKGROUND: We aimed to estimate lifetime cumulative risk of thyroid cancer (CRTC) in first-degree relatives of patients with non-medullary thyroid cancers (NMTC), including papillary (PTC)/follicular/oxyphilic/anaplastic thyroid carcinoma, by histology and age at diagnosis in patients and their relatives. DESIGN: A population-based cohort of 63 495 first-degree relatives of 11 206 NMTC patients diagnosed in 1955-2009 in Nordic countries was followed for cancer incidence. Standardised incidence ratios (SIRs) were calculated using histology-specific, age-specific, sex-specific, period-specific and country-specific incidence rates as reference. RESULTS: The 0-84-year CRTC in female relatives of a patient with PTC was 2%, representing a threefold increase over the general population risk (SIR=2.9, 95% CI 2.4 to 3.4; Men: CRTC=1%, SIR=2.5, 95% CI 1.9 to 3.3). When there were ≥2 PTC patients diagnosed at age <60 years in a family, CRTC for female relatives was 10% (male 24%). Twins had a 23-fold increased risk of concordant PTC. Family history of follicular/oxyphilic/anaplastic carcinoma increased CRTC in relatives to about 1-2%. Although no familial case of concordant oxyphilic/anaplastic carcinoma was found, familial risks of discordant histology types of NMTC were interchangeably high for most of the types, for example, higher risk of PTC when a first-degree relative had follicular (SIR=3.0, 95%CI 1.7 to 4.9) or anaplastic (SIR=3.6, 95% CI 1.2 to 8.4) carcinoma. The earlier a patient was diagnosed with PTC in a family, the higher was the SIR in his/her younger relatives. There was a tendency towards concordant age at diagnosis of thyroid cancer among relatives of PTC patients. CONCLUSIONS: This study provides clinically relevant risk estimates for family members of NMTC patients.
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Authors | Mahdi Fallah, Eero Pukkala, Laufey Tryggvadottir, Jörgen H Olsen, Steinar Tretli, Kristina Sundquist, Kari Hemminki |
Journal | Journal of medical genetics
(J Med Genet)
Vol. 50
Issue 6
Pg. 373-82
(Jun 2013)
ISSN: 1468-6244 [Electronic] England |
PMID | 23585692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adenocarcinoma, Follicular
(diagnosis, epidemiology, genetics, pathology)
- Adolescent
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Child
- Child, Preschool
- Family
- Female
- Humans
- Incidence
- Infant
- Infant, Newborn
- Male
- Middle Aged
- Risk
- Scandinavian and Nordic Countries
(epidemiology)
- Sex Factors
- Thyroid Neoplasms
(diagnosis, epidemiology, genetics, pathology)
- Young Adult
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