Abstract | OBJECTIVE: METHODS: RESULTS: The average serum concentration of TSP-1 was (200 ± 49) µg/L in prostate cancer group, (281 ± 53) µg/L in BPH group and (323 ± 56) µg/L in healthy control group. There were significant inter-group differences in the serum levels of TSP-1 (both P < 0.05). The average serum concentration of TSP-1 was (216 ± 34) µg/L in organ-confined prostate cancer (including stages I and II) and (188 ± 49) µg/L in non-organ-confined prostate cancer (including stages III and IV) respectively (P = 0.030). The level of TSP-1 was also correlated with Gleason score (r = -0.32, P = 0.023). However, the relationship between TSP-1 levels and lymph node metastasis remained elusive (P = 0.189). The diagnostic sensitivity and specificity of TSP-1 and prostate specific antigen (PSA) for prostate cancer were 72%, 90% and 64%, 70% respectively (both P < 0.05). The area under the receiver operating characteristic curve (ROC) of TSP-1 and PSA were 0.886 and 0.719 respectively (P = 0.028). CONCLUSION:
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Authors | Jian-cheng Lu, Ding-wei Ye, Wen-zhi Li, Li-huan Du, Wei Jin, Xue-qiang Lu, Ji-hong Zhang, Gang Chen |
Journal | Zhonghua yi xue za zhi
(Zhonghua Yi Xue Za Zhi)
Vol. 93
Issue 4
Pg. 252-5
(Jan 22 2013)
ISSN: 0376-2491 [Print] China |
PMID | 23578502
(Publication Type: English Abstract, Journal Article)
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Chemical References |
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Topics |
- Aged
- Aged, 80 and over
- Case-Control Studies
- Humans
- Male
- Middle Aged
- Prostatic Neoplasms
(blood, diagnosis)
- Sensitivity and Specificity
- Thrombospondin 1
(blood)
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