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Attenuation of gouty arthritis by emodinol in monosodium urate crystal-treated mice.

Abstract
A series of studies have recently demonstrated that the release of interleukin 1β induced by monosodium urate crystals is central to the experimental gouty arthritis. Elaeagnus pungens has been traditionally used for the treatment of gouty arthritis in China for more than thousands years. However, there is still little known about the active ingredients and mechanisms of E. pungens against gouty arthritis. Emodinol, as a major triterpene compound in E. pungens, has been seldom reported to have an effect on gouty arthritis. Therefore, the potential beneficial effects and mechanisms of emodinol on gouty arthritis were investigated in this study. Results showed that it significantly ameliorated the hyperalgesia, inflammation, and levels of multiple proinflammatory cytokines in monosodium urate crystals-treated mice. These findings elucidate that emodinol exhibits a prominent effect on improving symptoms of acute gouty arthritis induced by monosodium urate crystals through inhibiting the generation of proinflammatory cytokines.
AuthorsLvyi Chen, Zhou Lan, Shuwei Ma, Ling Zhao, Xinzhou Yang
JournalPlanta medica (Planta Med) Vol. 79 Issue 8 Pg. 634-8 (May 2013) ISSN: 1439-0221 [Electronic] Germany
PMID23576175 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightGeorg Thieme Verlag KG Stuttgart · New York.
Chemical References
  • 1beta, 3beta, 23-trihydroxyolean-12-en-28-oic acid
  • Interleukin-1beta
  • Interleukin-6
  • Plant Extracts
  • Tumor Necrosis Factor-alpha
  • Uric Acid
  • Oleanolic Acid
Topics
  • Animals
  • Arthritis, Gouty (chemically induced, drug therapy)
  • Elaeagnaceae (chemistry)
  • Enzyme-Linked Immunosorbent Assay
  • Interleukin-1beta (blood)
  • Interleukin-6 (blood)
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Oleanolic Acid (analogs & derivatives, therapeutic use)
  • Plant Extracts (therapeutic use)
  • Tumor Necrosis Factor-alpha (blood)
  • Uric Acid (administration & dosage)

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