Thrombocytosis as a potential cause of a very late stent thrombosis in the left main coronary artery.

A 36 year-old man, who had undergone a paclitaxel-eluting stent deployment into the left main (LM) coronary artery three years before, was admitted after successful resuscitation following out-of-hospital cardiac arrest due to an acute ST-segment elevation myocardial infarction. Six weeks before the admission, he had discontinued clopidogrel. Coronary angiography showed a total occlusion of the LM artery. A complex percutaneous coronary intervention including thrombectomy and a second everolimus-eluting stent deployment in the LM artery and the left descending coronary artery was performed; this resulted in the restoration of TIMI 2/3 flow. A detailed investigation revealed an essential thrombocytosis necessitating treatment with hydroxyurea and indefinite dual antiplatelet therapy.
AuthorsMarek Prech, Magdalena Janus, Konrad Lukawski, Maciej Lesiak
JournalKardiologia polska (Kardiol Pol) Vol. 71 Issue 3 Pg. 308-9 ( 2013) ISSN: 0022-9032 [Print] Poland
PMID23575792 (Publication Type: Case Reports, Journal Article)
Chemical References
  • clopidogrel
  • Ticlopidine
  • Paclitaxel
  • Adult
  • Coronary Angiography
  • Coronary Stenosis (etiology, radiography)
  • Coronary Thrombosis (etiology, radiography)
  • Drug-Eluting Stents (adverse effects)
  • Humans
  • Male
  • Myocardial Infarction (etiology, radiography, therapy)
  • Out-of-Hospital Cardiac Arrest (etiology, therapy)
  • Paclitaxel (administration & dosage)
  • Thrombocytosis (drug therapy, etiology)
  • Ticlopidine (administration & dosage, analogs & derivatives)
  • Withholding Treatment

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