Palisaded myofibroblastoma of the breast: a tumor closely mimicking schwannoma: Report of 2 cases.

Abstract

Myofibroblastoma is a relatively rare, benign mesenchymal tumor that typically occurs in the breast parenchyma. Unlike mammary-type myofibroblastoma, myofibroblastoma that primarily arises in the lymph nodes exhibits nuclear palisading, and the term palisaded myofibroblastoma has been proposed, accordingly. We report 2 unusual cases of myofibroblastoma of the male breast, which showed a predominant (>90% of the entire tumor) nuclear palisading and Verocay-like bodies. The present cases represent a hitherto unreported variant of mammary-type myofibroblastoma closely mimicking schwannoma. The diagnosis of myofibroblastoma was supported by immunohistochemical analyses showing a diffuse staining for desmin and CD34. In addition, the diagnosis of myofibroblastoma was confirmed in 1 case cytogenetically by the demonstration of the monoallelic loss of the FOXO1/13q14 locus by fluorescence in situ hybridization. Pathologists should be aware of this unusual variant of mammary myofibroblastoma to assure a correct diagnosis.

• Authors: Gaetano Magro, Maria Pia Foschini, Vincenzo Eusebi
• Journal: Human pathology (Hum Pathol) Vol. 44 Issue 9 Pg. 1941-6 (Sep 2013) ISSN: 1532-8392 [Electronic] United States
• PMID: 23574785 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Antigens, CD34
• Biomarkers, Tumor
• DNA, Neoplasm
• Desmin
• FOXO1 protein, human
• Forkhead Box Protein O1
• Forkhead Transcription Factors

Topics

• Aged
• Antigens, CD34 (metabolism)
• Biomarkers, Tumor (genetics, metabolism)
• Breast Neoplasms, Male (genetics, metabolism, pathology)
• Cell Nucleus (pathology)
• DNA, Neoplasm (analysis)
• Desmin (metabolism)
• Diagnosis, Differential
• Forkhead Box Protein O1
• Forkhead Transcription Factors (genetics, metabolism)
• Humans
• In Situ Hybridization, Fluorescence
• Male
• Mastectomy, Segmental
• Middle Aged
• Neoplasms, Muscle Tissue (genetics, metabolism, pathology)
• Neurilemmoma (diagnosis)
• Treatment Outcome