Abstract | BACKGROUND/AIMS: METHODOLOGY: Immunohistochemistry, VEGF-C expression and LVD were performed in 41 patients with gastric cancer invading the muscularis propria and 19 patients with GIST. The clinicopathological features of these cases were compared. RESULTS: CONCLUSIONS: These results indicate that the expression of VEGF-C is associated with tumor LVD and lymph node metastasis, suggesting that VEGF-C plays a critical role in node metastasis via lymphangiogenesis. The clinical observation that GIST rarely metastasizes to the lymph nodes may depend on the lack of VEGF-C expression.
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Authors | Wakako Kigure, Takaaki Fujii, Toshinaga Sutoh, Hiroki Morita, Toshihide Katoh, R Nreina Yajima, Sator Yamaguchi, Soichi Tsutsumi, Takayuki Asao, Hiroyuki Kuwano |
Journal | Hepato-gastroenterology
(Hepatogastroenterology)
2013 Mar-Apr
Vol. 60
Issue 122
Pg. 277-80
ISSN: 0172-6390 [Print] Greece |
PMID | 23574654
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- VEGFC protein, human
- Vascular Endothelial Growth Factor C
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Topics |
- Adult
- Aged
- Female
- Gastrointestinal Neoplasms
(pathology)
- Gastrointestinal Stromal Tumors
(pathology)
- Humans
- Lymphangiogenesis
- Lymphatic Metastasis
- Lymphatic Vessels
(pathology)
- Male
- Middle Aged
- Stomach Neoplasms
(pathology)
- Vascular Endothelial Growth Factor C
(analysis, physiology)
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