Abstract | BACKGROUND: OBJECTIVES:
Cyclosporine (CsA) assay is critical for the management of renal transplant recipients due to inter- and intra-patient variation in CsA absorption and metabolism. PATIENTS AND METHODS: In a retrospective cross sectional study, blood levels of CsA (through and 2 hours post dose) measured at least 5 times during 3 years post transplantation, in 7702 kidney transplant recipients from different transplant center of Tehran, IR Iran between 2008 and 2012. Cyclosporine absorption (CA) calculated C2/C0 ratio. RESULTS: CA had a significant correlation with allograft function (P = 0.000, r =.0.285), this correlation was stronger than its relationship with C0 and C2 blood levels (P = 0.000 and P = 0.000 as well as r = 0.033 and r = 0.090, respectively). In univariate analysis during different times after transplantation, C0 and C2 blood levels significantly decreased over three years follow up (P = 0.000), (P = 0.000); While, CA reversely increases over the time (P = 0.000). In linear regression model overall CA levels had correlation with lower age of recipient (P = 0.02), hypokalemia (P = 0.001), higher level of creatinine (P = 0.02) and triglyceride (P = 0.001). CONCLUSIONS: The present study shows that CsA absorption changes trough the post-transplant time and appears to increases over time in long-term period after kidney transplantation.
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Authors | Behzad Einollahi, Mojtaba Teimoori, Zohreh Rostami |
Journal | Nephro-urology monthly
(Nephrourol Mon)
Vol. 4
Issue 2
Pg. 470-4
( 2012)
ISSN: 2251-7006 [Print] Netherlands |
PMID | 23573469
(Publication Type: Journal Article)
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