HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Antitumor activity of 1-nitro-9-aminoacridines including nitracrine against some ascitic experimental tumors.

Abstract
The antitumor activity of a few 1-nitro-9-aminoacridine derivatives including nitracrine was evaluated against ascitic forms of murine tumors: Ehrlich carcinoma. Walker carcinosarcoma 256, and leukemia L1210. The studied compounds exhibited significant activity against ascitic Ehrlich carcinoma and very high activity against Walker carcinosarcoma. Leukemia L1210 on mice was not sensitive to the 1-nitro derivatives studied. On the basis of these results and the results reported earlier the following, specific biological properties exhibited by the derivatives studied were discussed: a) high activity against HeLa S3 and L1210 cells in vitro, but lack of activity against mice leukemia L1210; b) significant activity against some experimental and clinical tumors but not against leukemias, and c) lack of mammalian myelotoxicity.
AuthorsZ Mazerska, J Lukowicz, J Konopa
JournalArzneimittel-Forschung (Arzneimittelforschung) Vol. 40 Issue 4 Pg. 472-7 (Apr 1990) ISSN: 0004-4172 [Print] GERMANY, WEST
PMID2357249 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Aminoacridines
  • Antineoplastic Agents
  • Nitracrine
Topics
  • Aminoacridines (therapeutic use, toxicity)
  • Animals
  • Antineoplastic Agents (therapeutic use, toxicity)
  • Carcinoma 256, Walker (drug therapy)
  • Carcinoma, Ehrlich Tumor (drug therapy)
  • Lethal Dose 50
  • Leukemia L1210 (drug therapy)
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred DBA
  • Neoplasms, Experimental (drug therapy)
  • Nitracrine (analogs & derivatives, therapeutic use, toxicity)
  • Rats
  • Rats, Inbred Strains
  • Tumor Cells, Cultured (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: