A weight loss diet intervention has a similar beneficial effect on both metabolically abnormal obese and metabolically healthy but obese premenopausal women.

We studied the effect of a 12-week energy-restricted diet intervention on cardiometabolic risk in two groups of nonmorbid obese premenopausal Caucasian women, i.e. a metabolically abnormal obese (MAO) and a metabolically healthy but obese (MHO) group.
The participants were 53 MAO and 25 MHO women (age range 19-49 years; body mass index inclusion criterion: 30-39.9). We assessed changes in body weight and composition, blood lipids, insulin resistance, hepatic enzymes, inflammatory markers and adipocytokines.
Overall, many of the study outcomes improved with the intervention in both MAO and MHO participants, but there was no difference in the magnitude of change between the groups. Body weight, waist circumference and total fat mass decreased significantly in response to the intervention in both MAO and MHO women (all p < 0.001). Fasting insulin, insulin resistance (homeostasis model assessment), hepatic enzymes (alanine aminotransferase and γ-glutamyltransferase), fatty liver index and leptin levels also decreased in both groups after the intervention (all p < 0.001), whereas total cholesterol, triglycerides and C-reactive protein decreased significantly only in MAO women (all p < 0.001).
These findings reinforce the idea that MHO women would also benefit from a lifestyle weight reduction intervention.
AuthorsJonatan R Ruiz, Francisco B Ortega, Idoia Labayen
JournalAnnals of nutrition & metabolism (Ann Nutr Metab) Vol. 62 Issue 3 Pg. 223-30 ( 2013) ISSN: 1421-9697 [Electronic] Switzerland
PMID23571719 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 S. Karger AG, Basel.
Chemical References
  • C-Reactive Protein
  • Adiposity
  • Adult
  • Body Mass Index
  • C-Reactive Protein (analysis)
  • Diet, Reducing
  • Female
  • Humans
  • Hypercholesterolemia (etiology, prevention & control)
  • Hypertriglyceridemia (etiology, prevention & control)
  • Insulin Resistance
  • Life Style
  • Metabolic Syndrome X (blood, complications, diet therapy, physiopathology)
  • Middle Aged
  • Obesity (blood, complications, diet therapy)
  • Premenopause
  • Risk Factors
  • Waist Circumference
  • Weight Loss
  • Young Adult

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