Abstract | BACKGROUND/AIMS: We studied the effect of a 12-week energy-restricted diet intervention on cardiometabolic risk in two groups of nonmorbid obese premenopausal Caucasian women, i.e. a metabolically abnormal obese ( MAO) and a metabolically healthy but obese (MHO) group. METHODS: RESULTS: Overall, many of the study outcomes improved with the intervention in both MAO and MHO participants, but there was no difference in the magnitude of change between the groups. Body weight, waist circumference and total fat mass decreased significantly in response to the intervention in both MAO and MHO women (all p < 0.001). Fasting insulin, insulin resistance (homeostasis model assessment), hepatic enzymes ( alanine aminotransferase and γ-glutamyltransferase), fatty liver index and leptin levels also decreased in both groups after the intervention (all p < 0.001), whereas total cholesterol, triglycerides and C-reactive protein decreased significantly only in MAO women (all p < 0.001). CONCLUSION: These findings reinforce the idea that MHO women would also benefit from a lifestyle weight reduction intervention.
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Authors | Jonatan R Ruiz, Francisco B Ortega, Idoia Labayen |
Journal | Annals of nutrition & metabolism
(Ann Nutr Metab)
Vol. 62
Issue 3
Pg. 223-30
( 2013)
ISSN: 1421-9697 [Electronic] Switzerland |
PMID | 23571719
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Adiposity
- Adult
- Body Mass Index
- C-Reactive Protein
(analysis)
- Diet, Reducing
- Female
- Humans
- Hypercholesterolemia
(etiology, prevention & control)
- Hypertriglyceridemia
(etiology, prevention & control)
- Insulin Resistance
- Life Style
- Metabolic Syndrome
(blood, complications, diet therapy, physiopathology)
- Middle Aged
- Obesity
(blood, complications, diet therapy)
- Premenopause
- Risk Factors
- Waist Circumference
- Weight Loss
- Young Adult
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