Word list learning in patients with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy.

Abstract

BACKGROUND/AIMS:

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) is a rare hereditary disease that is characterized by a combination of progressive presenile dementia and sclerosing leukoencephalopathy with bone cysts. No quantitative information on verbal memory functioning in PLOSL patients compared with control subjects is available.

METHODS:

23 patients with PLOSL and 23 control subjects were examined with a version of the 10-word list-learning task. Learning curves were compared between the patients and the matched control subjects.

RESULTS:

Compared with the control subjects, PLOSL patients with moderate or severe dementia were impaired in both learning trials and delayed recall on the 10-word list-learning test.

CONCLUSION:

Progressive degeneration of brain structures affecting the hippocampus and the medial temporal lobe with advanced PLOSL disease contributes to an inefficient verbal learning process.

• Authors: Matti Vanhanen, Panu Hakola, Tuula Ilonen, Jari Tiihonen
• Journal: Dementia and geriatric cognitive disorders extra (Dement Geriatr Cogn Dis Extra) Vol. 3 Issue 1 Pg. 10-5 (Jan 2013) ISSN: 1664-5464 [Print] Switzerland
• PMID: 23569454 (Publication Type: Journal Article)