The etiology of
Cronkhite-Canada syndrome (CCS) remains unknown and many cases are refractory to treatment. Therefore, new
therapies are urgently needed. Furthermore, a number of CCS cases with gastrointestinal
carcinoma have been reported. Our patient had rapid onset of CCS and early development of colon
carcinoma associated with
adenomas. High anterior resection of the sigmoid colon and
ileostomy were performed, and her symptoms and endoscopic and histological findings improved. Helicobacter pylori eradication was carried out 2 years later, surgical closure of an ileal
fistula the following year. After 4 months, upper gastrointestinal endoscopy and colonoscopy showed that the CCS lesions had completely disappeared, and biopsies confirmed a normal stomach, duodenum, ileum and colon histologically. The patient has maintained remission for 2 years. The
clinical course of this case, showing complete regression of CCS lesions following abdominal
colectomy and H. pylori eradication, suggests the significance of H. pylori
infection in the treatment of CCS.