Association of TIMP-1 and TIMP-2 gene polymorphisms with progression of liver fibrosis in patients with type C chronic liver disease.

Abstract

We examined the association of TIMP-1 and TIMP-2 gene polymorphisms with the progression of chronic liver disease related to the hepatitis C virus (HCV). We used PCR to analyze 188 patients with HCV-related liver disease (95 with chronic hepatitis and 93 with cirrhosis) for TIMP-1 372 T/C and TIMP-2 -418 G/C polymorphisms. Comparing chronic hepatitis and cirrhosis, there were no significant differences in TIMP-1 and TIMP-2 gene polymorphisms. Among chronic hepatitis patients, TIMP-2 -418 G homozygotes showed significantly faster fibrosis progression than C carriers. Among cirrhotic patients, males with the TIMP-1 372 T allele developed cirrhosis at a younger age, and patients who were homozygous for the higher-transcription TIMP-2 -418 G allele had significantly lower serum albumin concentrations. These results suggest that faster progression of liver fibrosis could be associated with TIMP-2 -418 G homozygotes.

• Authors: Yuichiro Ikebuchi, Chihiro Ishida, Kinya Okamoto, Yoshikazu Murawaki
• Journal: Biochemical genetics (Biochem Genet) Vol. 51 Issue 7-8 Pg. 564-74 (Aug 2013) ISSN: 1573-4927 [Electronic] United States
• PMID: 23563628 (Publication Type: Journal Article)

Chemical References

• Serum Albumin
• TIMP1 protein, human
• TIMP2 protein, human
• Tissue Inhibitor of Metalloproteinase-1
• Tissue Inhibitor of Metalloproteinase-2

Topics

• Aged
• Alleles
• Disease Progression
• Female
• Genotype
• Hepatitis C (genetics)
• Homozygote
• Humans
• Liver Cirrhosis (genetics)
• Male
• Middle Aged
• Polymorphism, Genetic
• Serum Albumin (metabolism)
• Tissue Inhibitor of Metalloproteinase-1 (genetics)
• Tissue Inhibitor of Metalloproteinase-2 (genetics)