Cinnamtannin A2, a tetrameric procyanidin, increases GLP-1 and insulin secretion in mice.

Abstract

Procyanidins are oligomers and polymers of flavan-3-ols consisting of (-)-epicatechin subunits. In this study, we isolated and purified dimeric, trimeric and tetrameric procyanidins from cacao liquor and investigated their influence on the "incretin effect" as compared to the monomer, (-)-epicatechin in mice. Cinnamtannin A2 specifically increased the glucagon-like peptide-1 (GLP-1) and insulin secretion levels in the plasma after 60 min administration. As evidence of the action of insulin, activation of insulin receptor and insulin receptor substrate-1 was observed in the soleus muscle. These results indicate that the intake of cinnamtannin A2 may improve hyperglycemia through an incretin-like effect, accompanied by activation of the insulin-signaling pathway.

• Authors: Yoko Yamashita, Masaaki Okabe, Midori Natsume, Hitoshi Ashida
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 77 Issue 4 Pg. 888-91 ( 2013) ISSN: 1347-6947 [Electronic] England
• PMID: 23563558 (Publication Type: Journal Article)

Chemical References

• Anthocyanins
• Insulin
• cinnamtannin A2
• Glucagon-Like Peptide 1
• Receptor, Insulin

Topics

• Animals
• Anthocyanins (chemistry, pharmacology)
• Dimerization
• Glucagon-Like Peptide 1 (blood, metabolism)
• Insulin (blood, metabolism)
• Insulin Secretion
• Male
• Mice
• Mice, Inbred ICR
• Muscle, Skeletal (cytology, drug effects, metabolism)
• Phosphorylation (drug effects)
• Receptor, Insulin (metabolism)