A novel N6-substituted adenosine isolated from mi huan jun (Armillaria mellea) as a cerebral-protecting compound.

Abstract

Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. The structure of AMG-1 was proposed as being 6-(5-hydroxy-2-pyridyl-methylamino)-9-beta-ribofuranosylpurine (1) on the basis of its UV, mass, 1H-NMR, and 13C-NMR spectra.

• Authors: N Watanabe, T Obuchi, M Tamai, H Araki, S Omura, J S Yang, D Q Yu, X T Liang, J H Huan
• Journal: Planta medica (Planta Med) Vol. 56 Issue 1 Pg. 48-52 (Feb 1990) ISSN: 0032-0943 [Print] Germany
• PMID: 2356243 (Publication Type: Journal Article)

Chemical References

• 6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine
• Adenosine

Topics

• Adenosine (analogs & derivatives)
• Agaricales (analysis)
• Animals
• Brain (drug effects)
• Male
• Medicine, Chinese Traditional
• Mice
• Mice, Inbred ICR
• Molecular Structure
• Spectrum Analysis