Implications in the difference of anti-Mi-2 and -p155/140 autoantibody prevalence in two dermatomyositis cohorts from Mexico City and Guadalajara.

Abstract

INTRODUCTION:

Autoantibodies and clinical manifestations in polymyositis/dermatomyositis (PM/DM) are affected by both genetic and environmental factors. The high prevalence of DM and anti-Mi-2 in Central America is thought to be associated with the high UV index of the area. The prevalences of autoantibodies and the clinical manifestations of PM/DM were evaluated comparing two cohorts in Mexico.

METHODS:

Ninety-five Mexican patients with PM/DM (66 DM, 29 PM; 67 Mexico City, 28 Guadalajara) were studied. Autoantibodies were characterized by immunoprecipitation using 35S-methionine labeled K562 cell extract. Clinical information was obtained from medical records.

RESULTS:

DM represented 69% of PM/DM and anti-Mi-2 was the most common autoantibody (35%), followed by anti-p155/140 (11%); however, anti-Jo-1 was only 4%. The autoantibody profile in adult-onset DM in Mexico City versus Guadalajara showed striking differences: anti-Mi-2 was 59% versus 12% (P = 0.0012) whereas anti-p155/140 was 9% versus 35% (P = 0.02), respectively. A strong association of anti-Mi-2 with DM was confirmed and when clinical features of anti-Mi-2 (+) DM (n = 30) versus anti-Mi-2 (-) DM (n = 36) were compared, the shawl sign (86% versus 64%, P < 0.05) was more common in the anti-Mi-2 (+) group (P = 0.0001). Levels of creatine phosphokinase (CPK) were higher in those who were anti-Mi-2 (+) but they responded well to therapy.

CONCLUSIONS:

Anti-Mi-2 has a high prevalence in Mexican DM and is associated with the shawl sign and high CPK. The prevalence of anti-Mi-2 and anti-p155/140 was significantly different in Mexico City versus Guadalajara, which have a similar UV index. This suggests roles of factors other than UV in anti-Mi-2 antibody production.

• Authors: Marcelo H Petri, Minoru Satoh, Beatriz T Martin-Marquez, Raul Vargas-Ramírez, Luis J Jara, Miguel A Saavedra, Claudia Cruz-Gonzalez, Lilia Andrade-Ortega, Olga Vera-Lastra, Mario Salazar-Páramo, Rosa E Prieto-Parra, Laura Gonzalez-Lopez, Jorge I Gamez-Nava, Hermes U Ramírez-Sánchez, Jason Y F Chan, Steven J Ross, Edward K L Chan, Mónica Vázquez-Del Mercado
• Journal: Arthritis research & therapy (Arthritis Res Ther) Vol. 15 Issue 2 Pg. R48 (Apr 04 2013) ISSN: 1478-6362 [Electronic] England
• PMID: 23557279 (Publication Type: Journal Article)

Chemical References

• Autoantibodies
• Autoantigens
• CHD4 protein, human
• Mi-2 antibodies
• p140 autoantigen, human
• Mi-2 Nucleosome Remodeling and Deacetylase Complex

Topics

• Adult
• Autoantibodies (blood, immunology)
• Autoantigens (immunology)
• Dermatomyositis (blood, immunology)
• Female
• Humans
• Immunoprecipitation
• Male
• Mexico (epidemiology)
• Mi-2 Nucleosome Remodeling and Deacetylase Complex (immunology)
• Middle Aged
• Prevalence