Abstract | AIM: METHODS: RESULTS: Blueberry juice consumption significantly attenuates CCl4-induced rat hepatic fibrosis, which was associated with elevated expression of metallothionein (MT), increased SOD activity, reduced oxidative stress, and decreased levels of α-SMA and Col III in the liver. CONCLUSION: Our study suggests that dietary supplementation of blueberry juice can augment antioxidative capability of the liver presumably via stimulating MT expression and SOD activity, which in turn promotes HSC inactivation and thus decreases extracellular matrix collagen accumulation in the liver, and thereby alleviating hepatic fibrosis.
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Authors | Yuping Wang, Mingliang Cheng, Baofang Zhang, Fei Nie, Hongmei Jiang |
Journal | PloS one
(PLoS One)
Vol. 8
Issue 3
Pg. e58659
( 2013)
ISSN: 1932-6203 [Electronic] United States |
PMID | 23554912
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Actins
- Collagen Type III
- Drugs, Chinese Herbal
- dan-shao-hua-xian
- smooth muscle actin, rat
- Malondialdehyde
- Metallothionein
- Carbon Tetrachloride
- Superoxide Dismutase
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Topics |
- Actins
(genetics, metabolism)
- Animals
- Beverages
- Blueberry Plants
(chemistry)
- Carbon Tetrachloride
(adverse effects)
- Collagen Type III
(genetics, metabolism)
- Dietary Supplements
- Drugs, Chinese Herbal
(administration & dosage)
- Gene Expression
- Liver
(drug effects, metabolism, pathology)
- Liver Cirrhosis, Experimental
(chemically induced, metabolism, prevention & control)
- Male
- Malondialdehyde
(metabolism)
- Metallothionein
(genetics, metabolism)
- Rats
- Superoxide Dismutase
(metabolism)
- Up-Regulation
|