Hydrogen-rich saline protects against ultraviolet B radiation injury in rats.

Abstract

Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study, we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to induce skin injury. Hydrogen-rich saline and nitrogen-rich saline were administered to rats by intraperitoneal injection. Skin damage was detected by microscope after injury. UVB radiation had a significant affection in tumor necrosis factor alpha, interleukin (IL)-1β and IL-6 levels, tissue superoxide dismutase, malondialdehyde and nitric oxide activity. Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury. Hydrogen-rich saline protected against UVB radiation injury, possibly by reducing inflammation and oxidative stress.

• Authors: Ze Guo, Bingrong Zhou, Wei Li, Xuejun Sun, Dan Luo
• Journal: Journal of biomedical research (J Biomed Res) Vol. 26 Issue 5 Pg. 365-71 (Sep 2012) ISSN: 1674-8301 [Print] China
• PMID: 23554772 (Publication Type: Journal Article)