Abstract | PURPOSE: METHODS: RESULTS:
Nestin was expressed in 16/19 cases with no significant difference between patients with BM metastasis and those without BM metastasis. XIAP was identified in 18/19 tumor cases; the staining density was significantly lower in patients with bone marrow metastasis and those with unfavorable histology. VEGF-R1, VEGF-R2, and VEGF-B were expressed while VEGF-A and VEGF-D were not. Significantly, higher expression of VEGF-B was noted in patients with BM metastasis. CONCLUSION: Expression of VEGF-B and XIAP in neuroblastoma may play a role in the development of bone marrow metastasis. Given the limited number of patients in this study, a larger cohort is needed to validate these findings.
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Authors | J Osman, S Galli, M Hanafy, X Tang, A Ahmed |
Journal | Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
(Clin Transl Oncol)
Vol. 15
Issue 11
Pg. 953-8
(Nov 2013)
ISSN: 1699-3055 [Electronic] Italy |
PMID | 23553333
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- NES protein, human
- Nestin
- VEGFA protein, human
- VEGFB protein, human
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factor B
- Vascular Endothelial Growth Factor D
- X-Linked Inhibitor of Apoptosis Protein
- XIAP protein, human
- Vascular Endothelial Growth Factor Receptor-1
- Vascular Endothelial Growth Factor Receptor-2
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Topics |
- Adolescent
- Biomarkers, Tumor
(metabolism)
- Bone Marrow Neoplasms
(metabolism, secondary)
- Child
- Child, Preschool
- Female
- Follow-Up Studies
- Humans
- Immunoenzyme Techniques
- Infant
- Infant, Newborn
- Male
- Nestin
(metabolism)
- Neuroblastoma
(metabolism, pathology)
- Prognosis
- Vascular Endothelial Growth Factor A
(metabolism)
- Vascular Endothelial Growth Factor B
(metabolism)
- Vascular Endothelial Growth Factor D
(metabolism)
- Vascular Endothelial Growth Factor Receptor-1
(metabolism)
- Vascular Endothelial Growth Factor Receptor-2
(metabolism)
- X-Linked Inhibitor of Apoptosis Protein
(metabolism)
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