HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of topical tafluprost on optic nerve head blood flow in patients with myopic disc type.

AbstractPURPOSE:
To investigate the effect of topical tafluprost on optic disc blood flow in patients with myopic disc.
MATERIALS AND METHODS:
Forty-eight eyes in 24 patients with a myopic disc type (oval shaped) optic disc tilted to the temporal, with a crescent peripapillary atrophy were included in this study. Twenty-eight eyes were diagnosed as normal tension glaucoma and 20 eyes were in normal subjects. None had any treatment for glaucoma. Average age was 45.3±11.9 years. One eye was treated with topical tafluprost and the fellow eye served as the control. Ocular blood flow was measured by laser speckle flowgraphy (LSFG-NAVI) at 30, 60, 90, and 120 minutes after tafluprost administration, and the mean blur rate (MBR) on the optic disc was analyzed. Blood pressure and intraocular pressure (IOP) were recorded.
RESULTS:
In all subjects, topical tafluprost (a) significantly reduced IOP versus baseline from 60 minutes after treatment (baseline: 15.2±3.4 mm Hg, 60 min: 13.3±3.2 mm Hg, P=0.001, 90 min: 13.3±3.6 mm Hg, P=0.002, 120 min: 13.7±3.4 mm Hg, P=0.007); and (b) significantly increased the MBR versus baseline (60 min: +4.3±6.6%, P=0.008, 90 min: +5.0±4.9%, P<0.001, 120 min: +6.7±7.0%, P<0.001).
CONCLUSIONS:
Topical tafluprost increased MBR in the optic nerve head and significantly reduced IOP, effects that may represent beneficial treatment for glaucoma patients with a myopic disc type.
AuthorsSatoru Tsuda, Yu Yokoyama, Naoki Chiba, Naoko Aizawa, Yukihiro Shiga, Masayuki Yasuda, Shunji Yokokura, Takaaki Otomo, Nobuo Fuse, Toru Nakazawa
JournalJournal of glaucoma (J Glaucoma) 2013 Jun-Jul Vol. 22 Issue 5 Pg. 398-403 ISSN: 1536-481X [Electronic] United States
PMID23552835 (Publication Type: Journal Article)
Chemical References
  • Antihypertensive Agents
  • Ophthalmic Solutions
  • Prostaglandins F
  • tafluprost
Topics
  • Administration, Topical
  • Adult
  • Aged
  • Antihypertensive Agents (administration & dosage, therapeutic use)
  • Blood Flow Velocity (drug effects)
  • Blood Pressure (physiology)
  • Female
  • Humans
  • Intraocular Pressure (drug effects)
  • Laser-Doppler Flowmetry
  • Low Tension Glaucoma (drug therapy, physiopathology)
  • Male
  • Middle Aged
  • Myopia (physiopathology)
  • Ophthalmic Solutions
  • Optic Disk (blood supply)
  • Prostaglandins F (administration & dosage, therapeutic use)
  • Regional Blood Flow (drug effects)
  • Retinal Vessels (physiopathology)
  • Tomography, Optical Coherence
  • Tonometry, Ocular

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: