Abstract | PURPOSE: To investigate the effect of topical tafluprost on optic disc blood flow in patients with myopic disc. MATERIALS AND METHODS: Forty-eight eyes in 24 patients with a myopic disc type (oval shaped) optic disc tilted to the temporal, with a crescent peripapillary atrophy were included in this study. Twenty-eight eyes were diagnosed as normal tension glaucoma and 20 eyes were in normal subjects. None had any treatment for glaucoma. Average age was 45.3±11.9 years. One eye was treated with topical tafluprost and the fellow eye served as the control. Ocular blood flow was measured by laser speckle flowgraphy (LSFG-NAVI) at 30, 60, 90, and 120 minutes after tafluprost administration, and the mean blur rate (MBR) on the optic disc was analyzed. Blood pressure and intraocular pressure (IOP) were recorded. RESULTS: In all subjects, topical tafluprost (a) significantly reduced IOP versus baseline from 60 minutes after treatment (baseline: 15.2±3.4 mm Hg, 60 min: 13.3±3.2 mm Hg, P=0.001, 90 min: 13.3±3.6 mm Hg, P=0.002, 120 min: 13.7±3.4 mm Hg, P=0.007); and (b) significantly increased the MBR versus baseline (60 min: +4.3±6.6%, P=0.008, 90 min: +5.0±4.9%, P<0.001, 120 min: +6.7±7.0%, P<0.001). CONCLUSIONS: Topical tafluprost increased MBR in the optic nerve head and significantly reduced IOP, effects that may represent beneficial treatment for glaucoma patients with a myopic disc type.
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Authors | Satoru Tsuda, Yu Yokoyama, Naoki Chiba, Naoko Aizawa, Yukihiro Shiga, Masayuki Yasuda, Shunji Yokokura, Takaaki Otomo, Nobuo Fuse, Toru Nakazawa |
Journal | Journal of glaucoma
(J Glaucoma)
2013 Jun-Jul
Vol. 22
Issue 5
Pg. 398-403
ISSN: 1536-481X [Electronic] United States |
PMID | 23552835
(Publication Type: Journal Article)
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Chemical References |
- Antihypertensive Agents
- Ophthalmic Solutions
- Prostaglandins F
- tafluprost
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Topics |
- Administration, Topical
- Adult
- Aged
- Antihypertensive Agents
(administration & dosage, therapeutic use)
- Blood Flow Velocity
(drug effects)
- Blood Pressure
(physiology)
- Female
- Humans
- Intraocular Pressure
(drug effects)
- Laser-Doppler Flowmetry
- Low Tension Glaucoma
(drug therapy, physiopathology)
- Male
- Middle Aged
- Myopia
(physiopathology)
- Ophthalmic Solutions
- Optic Disk
(blood supply)
- Prostaglandins F
(administration & dosage, therapeutic use)
- Regional Blood Flow
(drug effects)
- Retinal Vessels
(physiopathology)
- Tomography, Optical Coherence
- Tonometry, Ocular
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