[Atrophic glossitis is attributed to cobalamin deficiency].

Abstract

PURPOSE:

To analyze the causes of atrophic glossitis(AG) and to explore the relationship between AG and serum cobalamin, folate levels.

METHODS:

A total of 213 patients with AG treated from Jan.1979 to Jun. 2010 were analyzed for the causes of AG. Serum cobalamin, folate levels and complete blood count were tested in newly enrolled AG patients from Sep. 2010 to Aug. 2011. All data were analyzed with SPSS 16.0 software package for Student's t test.

RESULTS:

There were 97 AG patients (45.4%) suffering from megaloblastic anemia (MA)/ macrocytosis. Among the 72 newly enrolled AG patients, fifty had cobalamin deficiency. Meanwhile, serum folate levels were increased in cobalamin deficiency group.

CONCLUSIONS:

Cobalamin deficiency is the common cause both of MA/macrocytosis and AG, also may be the main cause of AG. Furthermore, AG may be the early clinical manifestation of cobalamin deficiency.

• Authors: Jing-ci Zhu, Yu-feng Wang, Jing Sheng, Fu-xiang Chen, Guo-yao Tang
• Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology (Shanghai Kou Qiang Yi Xue) Vol. 22 Issue 1 Pg. 58-62 (Feb 2013) ISSN: 1006-7248 [Print] China
• PMID: 23552783 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Folic Acid
• Vitamin B 12

Topics

• Anemia, Megaloblastic
• Folic Acid
• Glossitis
• Humans
• Vitamin B 12
• Vitamin B 12 Deficiency