Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study.

Abstract

OBJECTIVE:

To assess the influence of infertility and fertility drugs on risk of ovarian tumors.

DESIGN:

Case-control study (Mayo Clinic Ovarian Cancer Study).

SETTING:

Ongoing academic study of ovarian cancer.

PATIENT(S):

A total of 1,900 women (1,028 with ovarian tumors and 872 controls, frequency matched on age and region of residence) who had provided complete information in a self-report questionnaire about history of infertility and fertility drug use.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Effect of infertility history, use of fertility drugs and oral contraception, and gravidity on the risk of ovarian tumor development, after controlling for potential confounders.

RESULT(S):

Among women who had a history of infertility, use of fertility drugs was reported by 44 (24%) of 182 controls and 38 (17%) of 226 cases. Infertile women who used fertility drugs were not at increased risk of developing ovarian tumors compared with infertile women who did not use fertility drugs; the adjusted odds ratio was 0.64 (95% CI, 0.37, 1.11). The findings were similar when stratified by gravidity and when analyzed separately for borderline versus invasive tumors.

CONCLUSION(S):

We found no statistically significant association between fertility drug use and risk of ovarian tumors. Further larger, prospective studies are needed to confirm this observation.

• Authors: Albert Asante, Phoebe H Leonard, Amy L Weaver, Ellen L Goode, Jani R Jensen, Elizabeth A Stewart, Charles C Coddington
• Journal: Fertility and sterility (Fertil Steril) Vol. 99 Issue 7 Pg. 2031-6 (Jun 2013) ISSN: 1556-5653 [Electronic] United States
• PMID: 23552324 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Published by Elsevier Inc.

Chemical References

• Fertility Agents, Female

Topics

• Aged
• Case-Control Studies
• Female
• Fertility
• Fertility Agents, Female (adverse effects)
• Gravidity
• Humans
• Incidence
• Infertility, Female (drug therapy, physiopathology)
• Logistic Models
• Middle Aged
• Minnesota (epidemiology)
• Multivariate Analysis
• Odds Ratio
• Ovarian Neoplasms (chemically induced, epidemiology)
• Pregnancy
• Prevalence
• Reproductive Techniques, Assisted (adverse effects)
• Risk Assessment
• Risk Factors
• Surveys and Questionnaires