Abstract | OBJECTIVES: Because antimicrobial therapy is often employed in the treatment of infectious dental implant complications, this study determined the occurrence of in vitro antibiotic resistance among putative peri-implantitis bacterial pathogens. METHODS: RESULTS: One or more cultivable submucosal bacterial pathogens, most often Prevotella intermedia/nigrescens or Streptococcus constellatus, were resistant in vitro to clindamycin, amoxicillin, doxycycline, or metronidazole in 46.7%, 39.2%, 25%, and 21.7% of the peri-implantitis subjects, respectively. Only 6.7% subjects revealed submucosal test species resistant in vitro to both amoxicillin and metronidazole, which were either S. constellatus (one subject) or ciprofloxacin-susceptible strains of gram-negative enteric rods/pseudomonads (seven subjects). Overall, 71.7% of the 120 peri-implantitis subjects exhibited submucosal bacterial pathogens resistant in vitro to one or more of the tested antibiotics. CONCLUSIONS:
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Authors | Thomas E Rams, John E Degener, Arie J van Winkelhoff |
Journal | Clinical oral implants research
(Clin Oral Implants Res)
Vol. 25
Issue 1
Pg. 82-90
(Jan 2014)
ISSN: 1600-0501 [Electronic] Denmark |
PMID | 23551701
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | © 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Chemical References |
- Metronidazole
- Clindamycin
- Ciprofloxacin
- Amoxicillin
- Doxycycline
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Amoxicillin
(pharmacology)
- Biofilms
(drug effects)
- Ciprofloxacin
(pharmacology)
- Clindamycin
(pharmacology)
- Doxycycline
(pharmacology)
- Drug Resistance, Microbial
- Female
- Humans
- Male
- Metronidazole
(pharmacology)
- Microbial Sensitivity Tests
- Middle Aged
- Peri-Implantitis
(drug therapy, microbiology)
- Retrospective Studies
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