Abstract | OBJECTIVE: METHODS: A total of 48 postoperative children were enrolled in the study between 2008 and 2010. Patients were stratified based upon choice of pulmonary vasodilator into three equal groups (n = 16); Milrinone group received intravenous milrinone (0.75 µ/kg/min), Sildenafil group received oral sildenafil (0.3 mg/kg every 3 hours) and the Combination group received both medications. FINDINGS: Demographic variables and types of congenital anomalies were not different among the 3 groups. Patients in the Combination group had higher preoperative pulmonary artery to aortic (PA/AO) pressure ratios compared to other two groups (P=0.001). Postoperatively, patients in Milrinone group incurred lower systolic PA and PA/AO pressures compared to Sildenafil group (P=0.014, 0.003), but it was the same in Sildenafil and Combination group (P=0.2; 0.330 respectively). Pulmonary hypertensive crisis was noted in 6 patients in Sildenafil group, and 3 patients in Combination group (P=0.02). Significant rise in PA pressure was noticed after discontinuation of drug in Milrinone group (P=0.001), which was not observed in the Combination group (P= 0.6). No mortality was noticed in any of the groups. CONCLUSION:
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Authors | Peiravian Farah, Amirghofran Ahmad-Ali, Ghamsari Hanane, Emaminia Abbas |
Journal | Iranian journal of pediatrics
(Iran J Pediatr)
Vol. 23
Issue 1
Pg. 19-26
(Feb 2013)
ISSN: 2008-2142 [Print] Netherlands |
PMID | 23550065
(Publication Type: Journal Article)
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