[Electrocardiographic predictors of response to cardiac resynchronization therapy of heart failure in patients with dilated cardiomyopathy].

Abstract

UNLABELLED:

The aim of our study was to identify electrocardiographic predictors of response to cardiac resynchronization therapy (CRT) in patients with dilated cardiomyopathy (DCM).

METHODS:

46 patients with DCM (76% men; mean age 48.8+/-12 years; mean NYHA class 3.09+/-0.3; mean QRS duration 167+/-30.1 ms; left ventricular ejection fraction 23.5+/-6%) had CRT implanted. Assessment of clinical, laboratory and echocardiographic (including TDI) and 12-lead surface ECG parameters was performed at baseline, in 24 hours post CRT implantation and after 6 months of follow-up. Multivariate logistic regression analysis selected the following independent predictors of response to CRT: two pre-implantation - baseline RS width in lead V1 ≥ 113.5 ms (OR 0.94, 95% CI 0.814-1.00; p=0.000), BNP ≤ 456 g/ml (OR 0.92, 95% CI 0.797-1.00; p=0.001); and two post-implantation: shortening of QRS width - ΔQRS ≥ -24.5 ms (OR 0.80, 95% CI 0.586-1.00; p=0.01) and shortening of RS V1 width - ΔRSV1 ≥ -21.8 ms (S: 0.87, 95% CI 0.72-1.00; p= 0.002) in 24 hours after CRT.

• Authors: T G Vaĭkhanskaia, T V Kurushko, I V Sidorenko, T M Koptiukh, L M Gul', O P Mel'nikova, V F Golenishcha, O N Kovalenko
• Journal: Kardiologiia (Kardiologiia) Vol. 53 Issue 3 Pg. 48-54 ( 2013) ISSN: 0022-9040 [Print] Russia (Federation)
• PMID: 23548427 (Publication Type: Journal Article)

Topics

• Adult
• Cardiac Resynchronization Therapy (methods)
• Cardiac Resynchronization Therapy Devices
• Cardiomyopathy, Dilated (complications, diagnosis, physiopathology)
• Defibrillators, Implantable
• Electrocardiography (methods)
• Female
• Heart Failure (diagnosis, etiology, physiopathology, therapy)
• Humans
• Logistic Models
• Male
• Middle Aged
• Monitoring, Physiologic (methods)
• Outcome Assessment, Health Care (methods)
• Predictive Value of Tests
• Severity of Illness Index
• Stroke Volume