Long-term follow-up of severely symptomatic women with adenomyoma treated with combination therapy.

Abstract

OBJECTIVE:

The aim of our study was to assess the long-term efficacy of conservative surgery combined with gonadotropin-releasing hormone agonist therapy for uterine adenomyoma.

MATERIALS AND METHODS:

We carried out an uncontrolled descriptive study of 285 women who had symptomatic uterine adenomyoma. A total of 186 women with pathologically proven adenomyoma underwent ultramini-laparoscopic adenomyomectomy and a 6-month course of goserelin acetate treatment, and were evaluated semi-annually during a follow-up period of at least 3 years.

RESULTS:

Patient scores for dysmenorrhea using a self-reported six-point verbal numeric rating scale significantly declined compared with the baseline assessment, from 3.84 ± 0.65 to 0.33 ± 0.57, 0.52 ± 0.86, and 0.88 ± 1.29 at the end of the 1-, 2-, and 3-year follow-up visits, respectively (p < 0.001). Similar reductions were observed for analgesic usage scores. Menorrhagia scores significantly decreased compared with the baseline assessment, from 3.45 ± 1.46 to 0.42 ± 0.59, 0.65 ± 0.83, and 1.1 ± 1.34 at the end of the 1-, 2-, and 3-year follow-up visits, respectively (p < 0.001).

CONCLUSION:

Combination therapy for adenomyoma provides an effective treatment option for long-term symptom control and uterine preservation in severely symptomatic women for whom previous long-term drug therapy has failed or proven to be intolerable.

• Authors: Wei-Min Liu, Ching-Hui Chen, Li-Hsuan Chiu, Chii-Ruey Tzeng
• Journal: Taiwanese journal of obstetrics & gynecology (Taiwan J Obstet Gynecol) Vol. 52 Issue 1 Pg. 85-9 (Mar 2013) ISSN: 1875-6263 [Electronic] China (Republic : 1949- )
• PMID: 23548225 (Publication Type: Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013. Published by Elsevier B.V.

Chemical References

• Antineoplastic Agents, Hormonal
• Goserelin

Topics

• Adenomyoma (complications, therapy)
• Adolescent
• Adult
• Antineoplastic Agents, Hormonal (therapeutic use)
• Chemotherapy, Adjuvant
• Drug Administration Schedule
• Dysmenorrhea (etiology)
• Female
• Follow-Up Studies
• Goserelin (therapeutic use)
• Humans
• Kaplan-Meier Estimate
• Laparoscopy
• Menorrhagia (etiology)
• Middle Aged
• Severity of Illness Index
• Treatment Outcome
• Uterine Neoplasms (complications, therapy)
• Uterus (surgery)
• Young Adult