Abstract | AIM: MATERIALS AND METHODS: Twenty-seven patients with clinical and mycological diagnosis of DDC were enrolled and treated with 2 daily applications for 14 days and were followed-up for 2 further weeks. RESULTS: Three etiologic agents were isolated: Candida albicans in 88.8 %, Candida parapsilosis in 7.3 %, and Candida glabrata in 3.2 %. There was an average symptom reduction from 7.1 to 3.2 in the middle of treatment and to 1.2 and 0.4 units at the end of treatment and follow-up, respectively. The treatment evaluation at the end of the follow-up period showed a total clinical and mycological cure in 88.8 %, improvement in 3.7 %, and failure in 7.4 %. There was side effect (3.7 %) of skin irritation, but the drug was not discontinued. CONCLUSIONS: Based on its safety and effectiveness, sertaconazole cream may be considered a new alternative for DDC treatment.
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Authors | Alexandro Bonifaz, Andrés Tirado-Sánchez, María José Graniel, Carlos Mena, Adriana Valencia, Rosa María Ponce-Olivera |
Journal | Mycopathologia
(Mycopathologia)
Vol. 175
Issue 3-4
Pg. 249-54
(Apr 2013)
ISSN: 1573-0832 [Electronic] Netherlands |
PMID | 23546772
(Publication Type: Journal Article)
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Chemical References |
- Antifungal Agents
- Imidazoles
- Thiophenes
- sertaconazole
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Topics |
- Administration, Topical
- Antifungal Agents
(administration & dosage, adverse effects)
- Candida
(classification, isolation & purification)
- Candidiasis
(drug therapy, microbiology, pathology)
- Diaper Rash
(drug therapy, microbiology, pathology)
- Drug-Related Side Effects and Adverse Reactions
(epidemiology, pathology)
- Female
- Humans
- Imidazoles
(administration & dosage, adverse effects)
- Infant
- Male
- Thiophenes
(administration & dosage, adverse effects)
- Treatment Outcome
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