Abstract | BACKGROUND:
Erythromelalgia is an uncommon neurovascular disorder characterized by redness, increased skin temperature, and pain that usually occurs in the extremities. Treatment remains challenging because of its varying response to medical therapy. The objective of this study was to assess the response of erythromelalgia to compounded topical amitriptyline- ketamine. METHODS: RESULTS: Thirty-two patients (89%) were female. Mean (standard deviation) age was 44.7 (15.8) years (range, 5-74 years). Patients applied the medication 1 to 6 times per day (median, 5 times). One patient (3%) had complete relief from symptoms, 14 (39%) had substantial relief, 12 (33%) had some relief, 7 (19%) had no relief, and 2 (6%) had local worsening of symptoms. No patients had systemic adverse effects. CONCLUSIONS:
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Authors | Timothy J Poterucha, William T Weiss, Roger A Warndahl, Richard H Rho, Paola Sandroni, Mark D P Davis, Sinead L Murphy |
Journal | Journal of drugs in dermatology : JDD
(J Drugs Dermatol)
Vol. 12
Issue 3
Pg. 308-10
(Mar 2013)
ISSN: 1545-9616 [Print] United States |
PMID | 23545913
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Analgesics
- Analgesics, Non-Narcotic
- Drug Combinations
- Amitriptyline
- Ketamine
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Topics |
- Administration, Cutaneous
- Adolescent
- Adult
- Aged
- Amitriptyline
(administration & dosage, therapeutic use)
- Analgesics
(administration & dosage, therapeutic use)
- Analgesics, Non-Narcotic
(administration & dosage, therapeutic use)
- Child
- Child, Preschool
- Drug Combinations
- Erythromelalgia
(drug therapy, physiopathology)
- Female
- Humans
- Ketamine
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Retrospective Studies
- Young Adult
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