Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris.

Abstract

This study evaluated the tolerance and efficacy of 2 facial skin products in subjects with acne using the following acne treatments: 1) treatment A, a combination of salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid, and 2) treatment B (BenzaClin®, clindamycin 1% and benzoyl peroxide 5% gel). The treatment design included the split-face application of treatment A and treatment B and the full-face application of the cleanser, moisturizer, and sunscreen. Data were collected through physician visual assessments, subject irritation questionnaires and assessments, along with clinical photography. Results showed similar tolerance and efficacy for both treatments.

• Authors: Leslie S Baumann, Christian Oresajo, Margarita Yatskayer, Amanda Dahl, Kristian Figueras
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 12 Issue 3 Pg. 266-9 (Mar 2013) ISSN: 1545-9616 [Print] United States
• PMID: 23545907 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Dermatologic Agents
• Drug Combinations
• Gels
• Sunscreening Agents
• clindamycin phosphate benzoyl peroxide combination
• Clindamycin
• Benzoyl Peroxide

Topics

• Acne Vulgaris (drug therapy, pathology)
• Administration, Cutaneous
• Adolescent
• Adult
• Benzoyl Peroxide (administration & dosage, adverse effects, therapeutic use)
• Clindamycin (administration & dosage, adverse effects, therapeutic use)
• Dermatologic Agents (administration & dosage, adverse effects, therapeutic use)
• Drug Combinations
• Female
• Gels
• Humans
• Male
• Single-Blind Method
• Skin Care (methods)
• Sunscreening Agents (administration & dosage)
• Surveys and Questionnaires
• Treatment Outcome
• Young Adult