HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Sustained-release diltiazem in patients with effort angina and severe coronary artery sclerosis.

Abstract
Two case histories are presented. Patient 1 was an agricultural worker, aged 63 years, whose attacks of chest pain, diagnosed as effort angina, were relieved by sublingual nitroglycerin. An exercise test revealed ST segment depression of 2 mV in lead V5 of the electrocardiogram. Coronary arteriography disclosed 99% stenosis with delay in segments 7 and 14, 90% stenosis in segment 10, and 25% stenosis in segment 1. Treatment with 100 mg of sustained-release diltiazem relieved some of the symptoms; when the dose was increased to 200 mg daily, no further chest pains were experienced. Patient 2 was a restaurant owner, aged 61 years, who reported attacks of chest pain during physical work. An exercise test revealed ST segment depression of 2 mV in lead aVF; coronary arteriography showed 99% stenosis in segment 7, 75% stenosis in segment 9, and 50% stenosis in segment 10. No attacks of chest pain were experienced after treatment with 200 mg of sustained-release diltiazem daily. Blood pressure, heart rate, and the rate-pressure product fell in both patients after diltiazem treatment.
AuthorsT Mizuki, Y Nakashima, K Segawa, A Kuroiwa
JournalClinical therapeutics (Clin Ther) 1990 Mar-Apr Vol. 12 Issue 2 Pg. 172-80 ISSN: 0149-2918 [Print] UNITED STATES
PMID2354487 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Diltiazem
Topics
  • Angina Pectoris (drug therapy, physiopathology)
  • Angiocardiography
  • Blood Pressure (drug effects)
  • Coronary Disease (drug therapy, physiopathology)
  • Delayed-Action Preparations
  • Diltiazem (administration & dosage, therapeutic use)
  • Electrocardiography
  • Exercise Test
  • Female
  • Heart Function Tests
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: