Sustained-release diltiazem in patients with effort angina and severe coronary artery sclerosis.

Two case histories are presented. Patient 1 was an agricultural worker, aged 63 years, whose attacks of chest pain, diagnosed as effort angina, were relieved by sublingual nitroglycerin. An exercise test revealed ST segment depression of 2 mV in lead V5 of the electrocardiogram. Coronary arteriography disclosed 99% stenosis with delay in segments 7 and 14, 90% stenosis in segment 10, and 25% stenosis in segment 1. Treatment with 100 mg of sustained-release diltiazem relieved some of the symptoms; when the dose was increased to 200 mg daily, no further chest pains were experienced. Patient 2 was a restaurant owner, aged 61 years, who reported attacks of chest pain during physical work. An exercise test revealed ST segment depression of 2 mV in lead aVF; coronary arteriography showed 99% stenosis in segment 7, 75% stenosis in segment 9, and 50% stenosis in segment 10. No attacks of chest pain were experienced after treatment with 200 mg of sustained-release diltiazem daily. Blood pressure, heart rate, and the rate-pressure product fell in both patients after diltiazem treatment.
AuthorsT Mizuki, Y Nakashima, K Segawa, A Kuroiwa
JournalClinical therapeutics (Clin Ther) 1990 Mar-Apr Vol. 12 Issue 2 Pg. 172-80 ISSN: 0149-2918 [Print] UNITED STATES
PMID2354487 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Delayed-Action Preparations
  • Diltiazem
  • Angina Pectoris (drug therapy, physiopathology)
  • Angiocardiography
  • Blood Pressure (drug effects)
  • Coronary Disease (drug therapy, physiopathology)
  • Delayed-Action Preparations
  • Diltiazem (administration & dosage, therapeutic use)
  • Electrocardiography
  • Exercise Test
  • Female
  • Heart Function Tests
  • Heart Rate (drug effects)
  • Humans
  • Male
  • Middle Aged

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