Abstract | OBJECTIVES: BACKGROUND:
Biomarkers to predict the development of PAD are lacking. OxPL circulate in plasma, are transported by Lp(a), and deposit in the vascular wall and induce local inflammation. METHODS: The study population included 2 parallel nested case-control studies of 143 men within the Health Professionals Follow-up Study (1994 to 2008) and 144 women within the Nurses' Health Study (1990 to 2010) with incident confirmed cases of clinically significant PAD, matched 1:3 to control subjects. RESULTS: Levels of OxPL/ apoB were positively associated with risk of PAD in men and women: pooled relative risk: 1.37, 95% confidence interval: 1.19 to 1.58 for each 1-SD increase after adjusting age, smoking, fasting status, month of blood draw, lipids, body mass index, and other cardiovascular disease risk factors. Lp(a) was similarly associated with risk of PAD (pooled adjusted relative risk: 1.36; 95% confidence interval: 1.18 to 1.57 for each 1-SD increase). Autoantibodies to MDA- LDL and ApoB-IC were not consistently associated with risk of PAD. CONCLUSIONS:
OxPL/ apoB were positively associated with risk of PAD in men and women. The major lipoprotein carrier of OxPL, Lp(a), was also associated with risk of PAD, reinforcing the key role of OxPL in the pathophysiology of atherosclerosis mediated by Lp(a).
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Authors | Monica L Bertoia, Jennifer K Pai, Jun-Hee Lee, Adam Taleb, Michel M Joosten, Murray A Mittleman, Xiaohong Yang, Joseph L Witztum, Eric B Rimm, Sotirios Tsimikas, Kenneth J Mukamal |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 61
Issue 21
Pg. 2169-79
(May 28 2013)
ISSN: 1558-3597 [Electronic] United States |
PMID | 23541965
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Apolipoprotein B-100
- Apolipoproteins B
- Biomarkers
- Lipoprotein(a)
- Lipoproteins, LDL
- Phospholipids
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Topics |
- Adult
- Aged
- Apolipoprotein B-100
(blood)
- Apolipoproteins B
(blood)
- Biomarkers
(blood)
- Female
- Follow-Up Studies
- Humans
- Lipoprotein(a)
(blood)
- Lipoproteins, LDL
(blood)
- Male
- Middle Aged
- Oxidation-Reduction
- Peripheral Arterial Disease
(blood)
- Phospholipids
(blood)
- Prospective Studies
- Risk Factors
- Severity of Illness Index
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