Abstract | BACKGROUND: METHODS: The Shanghai Bladder Cancer Study enrolled 581 incident bladder cancer cases and 604 population controls. Each participant was solicited for his/her history of tobacco use and other lifestyle factors and donation of blood and urine specimens. Red blood cell lysates were used to quantify both hemoglobin adducts of 4-ABP and 2,6-DMA. Urine samples were used to quantify total cotinine. ORs and 95% confidence intervals (CI) for bladder cancer were estimated using unconditional logistic regression methods. RESULTS: Among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for low (below median of positive values) and high versus undetectable levels of 2,6-DMA hemoglobin adducts were 3.87 (1.39-10.75) and 6.90 (3.17-15.02), respectively (Ptrend < 0.001). Similarly, among lifelong nonsmokers, ORs (95% CIs) of bladder cancer for third and fourth versus first/second quartiles of 4-ABP hemoglobin adducts was 1.30 (0.76-2.22) and 2.29 (1.23-4.24), respectively (Ptrend = 0.009). The two associations were independent of each other. CONCLUSION:
Hemoglobin adducts of 4-ABP and 2,6-DMA were significantly and independently associated with increased bladder cancer risk among lifelong nonsmokers in Shanghai, China. IMPACT: The findings of the present study in China with previous data in Los Angeles, California strongly implicate arylamines as potential causal agents of human bladder cancer.
|
Authors | Li Tao, Billy W Day, Bibin Hu, Yong-Bing Xiang, Renwei Wang, Mariana C Stern, Manuela Gago-Dominguez, Victoria K Cortessis, David V Conti, David Van Den Berg, Malcolm C Pike, Yu-Tang Gao, Mimi C Yu, Jian-Min Yuan |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 22
Issue 5
Pg. 937-45
(May 2013)
ISSN: 1538-7755 [Electronic] United States |
PMID | 23539508
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Aniline Compounds
- Biomarkers, Tumor
- Hemoglobins
- hemoglobin, 4-aminobiphenyl-
- 2,6-xylidine
|
Topics |
- Aged
- Aniline Compounds
(blood)
- Biomarkers, Tumor
(blood)
- Case-Control Studies
- Female
- Hemoglobins
(metabolism)
- Humans
- Male
- Middle Aged
- Risk Factors
- Smoking
(blood, urine)
- Urinary Bladder Neoplasms
(blood, urine)
|