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Acute toxicity of methyl isocyanate in mammals. II. Induction of hyperglycemia, lactic acidosis, uraemia, and hypothermia in rats.

Abstract
When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocyte acetyl cholinesterase activity. Irrespective of the route of administration, MIC also caused severe hypothermia, which was not ameliorated by prior administration of atropine sulphate. Acute toxic effects of MIC are essentially similar by either route except for the intensity of the effects.
AuthorsK Jeevaratnam, R Vijayaraghavan, M P Kaushik, C S Vaidyanathan
JournalArchives of environmental contamination and toxicology (Arch Environ Contam Toxicol) 1990 May-Jun Vol. 19 Issue 3 Pg. 314-8 ISSN: 0090-4341 [Print] United States
PMID2353832 (Publication Type: Journal Article)
Chemical References
  • Blood Glucose
  • Cyanates
  • Isocyanates
  • methyl isocyanate
Topics
  • Acidosis, Lactic (chemically induced)
  • Animals
  • Blood Glucose (metabolism)
  • Cyanates (toxicity)
  • Hyperglycemia (chemically induced)
  • Hypothermia (chemically induced)
  • Isocyanates
  • Male
  • Rats
  • Rats, Inbred Strains
  • Uremia (chemically induced)

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