Abstract |
When rats were administered methyl isocyanate (MIC) by inhalation or subcutaneous route it produced severe hyperglycemia, clinical lactic acidosis, highly elevated plasma urea, and reduced plasma cholinesterase activity with unaltered erythrocyte acetyl cholinesterase activity. Irrespective of the route of administration, MIC also caused severe hypothermia, which was not ameliorated by prior administration of atropine sulphate. Acute toxic effects of MIC are essentially similar by either route except for the intensity of the effects.
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Authors | K Jeevaratnam, R Vijayaraghavan, M P Kaushik, C S Vaidyanathan |
Journal | Archives of environmental contamination and toxicology
(Arch Environ Contam Toxicol)
1990 May-Jun
Vol. 19
Issue 3
Pg. 314-8
ISSN: 0090-4341 [Print] United States |
PMID | 2353832
(Publication Type: Journal Article)
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Chemical References |
- Blood Glucose
- Cyanates
- Isocyanates
- methyl isocyanate
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Topics |
- Acidosis, Lactic
(chemically induced)
- Animals
- Blood Glucose
(metabolism)
- Cyanates
(toxicity)
- Hyperglycemia
(chemically induced)
- Hypothermia
(chemically induced)
- Isocyanates
- Male
- Rats
- Rats, Inbred Strains
- Uremia
(chemically induced)
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