Protective effects of antioxidants against endrin-induced lipid peroxidation, glutathione depletion, and lethality in rats.

Abstract

Endrin depletes glutathione levels and induces lipid peroxidation in various species of animals. We have, therefore, examined the effect of antioxidants on these parameters in endrin-treated rats. Butylated hydroxyanisole (BHA), vitamin E, vitamin C, and the glutathione precursor cysteine significantly inhibited hepatic glutathione depletion and lipid peroxidation induced by 4 mg endrin/kg body weight. Furthermore, these antioxidants provided partial protection against lethality produced by 8 mg endrin/kg body weight. These results suggest but do not prove that free radical-mediated lipid peroxidation and glutathione depletion may be involved in the toxic manifestations of endrin.

• Authors: I T Numan, M Q Hassan, S J Stohs
• Journal: Archives of environmental contamination and toxicology (Arch Environ Contam Toxicol) 1990 May-Jun Vol. 19 Issue 3 Pg. 302-6 ISSN: 0090-4341 [Print] United States
• PMID: 2353831 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Glutathione
• Endrin

Topics

• Animals
• Antioxidants (pharmacology)
• Endrin (antagonists & inhibitors, toxicity)
• Female
• Glutathione (physiology)
• Lipid Peroxidation (drug effects)
• Rats
• Rats, Inbred Strains