Clinical impact and reliability of carbonic anhydrase XII in the differentiation of malignant and tuberculous pleural effusions.

Abstract

OBJECTIVE:

To assess the practical utility of pleural fluid carbonic anhydrase XII (CAXII) quantification for differential diagnosis of effusions.

MATERIALS AND METHODS:

Fluid was collected prospectively from fifty patients presenting with lymphocytic pleural effusions for investigation and CAXII was quantified by ELISA.

RESULTS:

Pleural fluid CAXII concentrations were significantly higher in lung cancer patients (n=30) than in tuberculous controls (n=20). The sensitivity and specificity of this biomarker were 60%and 75%, respectively. CAXII measurement was not inferior to cytological examination in the diagnosis and exclusion of pleural effusions from lung cancer patients (sensitivity 60% vs. 57%; specificity 75% vs. 100%; positive predictive value 77%; negative predictive value 54%). In patients with negative cytology, it offered a sensitivity of 54%.

CONCLUSIONS:

Pleural fluid CAXII is elevated in pleural effusions from lung cancer patients. Measurement of CAXII may be used in the future as a valuable adjunct to cytology in the diagnostic assessment of patients with pleural effusions related to lung cancer, especially when cytological examination is inconclusive.

• Authors: Yun-Long Liu, Li-Ling Jing, Qi-Sen Guo
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 1 Pg. 351-4 ( 2013) ISSN: 2476-762X [Electronic] Thailand
• PMID: 23534752 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Carbonic Anhydrases
• carbonic anhydrase XII

Topics

• Adenocarcinoma (complications, enzymology)
• Adult
• Aged
• Analysis of Variance
• Area Under Curve
• Carbonic Anhydrases (metabolism)
• Carcinoma, Squamous Cell (complications, enzymology)
• Cytodiagnosis
• Diagnosis, Differential
• Female
• Humans
• Lung Neoplasms (complications, enzymology, pathology)
• Male
• Middle Aged
• Pleural Effusion (diagnosis, enzymology, microbiology)
• Pleural Effusion, Malignant (diagnosis, enzymology, etiology)
• ROC Curve
• Small Cell Lung Carcinoma (complications, enzymology)
• Tuberculosis, Pleural (complications, enzymology)