Abstract | OBJECTIVE: To determine the pharmacokinetics, pharmacodynamics, and safety of zoledronic acid in horses. ANIMALS: 8 healthy horses. PROCEDURES: A single dose of zoledronic acid (0.057 mg/kg, IV) was administered during a 30-minute period. Venous blood was collected at several time points. Zoledronic acid concentration in plasma was measured by liquid chromatography-tandem mass spectrometry, and pertinent pharmacokinetic parameters were determined. Plasma was analyzed for total calcium, BUN, and creatinine concentrations and a marker for bone resorption (C-terminal telopeptides of type I collagen). RESULTS:
Zoledronic acid was safely administered IV during a 30-minute period, and no adverse effects were observed. Plasma concentrations of zoledronic acid were consistent with a 2-compartment mammillary model. Plasma concentrations of zoledronic acid were detected for up to 8 hours after administration. Mean total calcium concentrations in plasma were less than the reference range 7 days after zoledronic acid administration. A marker for bone remodeling decreased in concentration after zoledronic acid administration and remained low for the 1-year duration of the study. No changes in BUN and creatinine concentrations were observed after zoledronic acid administration. CONCLUSIONS AND CLINICAL RELEVANCE:
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Authors | Jorge E Nieto, Omar Maher, Scott D Stanley, Heather K Knych, Jack R Snyder |
Journal | American journal of veterinary research
(Am J Vet Res)
Vol. 74
Issue 4
Pg. 550-6
(Apr 2013)
ISSN: 1943-5681 [Electronic] United States |
PMID | 23531062
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bone Density Conservation Agents
- Diphosphonates
- Imidazoles
- Zoledronic Acid
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Topics |
- Animals
- Area Under Curve
- Bone Density Conservation Agents
(adverse effects, blood, pharmacokinetics)
- Diphosphonates
(adverse effects, blood, pharmacokinetics)
- Female
- Half-Life
- Horses
(blood, metabolism)
- Imidazoles
(adverse effects, blood, pharmacokinetics)
- Male
- Zoledronic Acid
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