Abstract | BACKGROUND: METHODS: RESULTS: We show that type IV collagen is expressed close to the cancer cells in vivo, forming basement membrane like structures on the cancer cell surface that colocalize with the integrin receptors. Furthermore, the interaction between type IV collagen produced by the cancer cell, and integrins on the surface of the cancer cells, are important for continuous cancer cell growth, maintenance of a migratory phenotype, and for avoiding apoptosis. CONCLUSION:
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Authors | Daniel Öhlund, Oskar Franklin, Erik Lundberg, Christina Lundin, Malin Sund |
Journal | BMC cancer
(BMC Cancer)
Vol. 13
Pg. 154
(Mar 26 2013)
ISSN: 1471-2407 [Electronic] England |
PMID | 23530721
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Collagen Type I
- Collagen Type IV
- Integrins
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Topics |
- Apoptosis
(genetics)
- Autocrine Communication
(genetics)
- Cell Line, Tumor
- Cell Movement
(genetics)
- Cell Proliferation
- Collagen Type I
(genetics, metabolism)
- Collagen Type IV
(genetics, metabolism)
- Gene Expression
- Humans
- Integrins
(metabolism)
- Pancreatic Neoplasms
(genetics, metabolism)
- Protein Binding
- RNA Interference
- Stromal Cells
(metabolism)
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