Increased expression of neurotrophin 4 following focal cerebral ischemia in adult rat brain with treadmill exercise.

Abstract

Neurotrophin 4 (NT-4) belongs to the family of neurotrophic factors, and it interacts with the tyrosine kinase B (trkB) receptor. NT-4 has neuroprotective effects following cerebral ischemia. Its role might be similar to brain-derived neurotrophic factor (BDNF), because both interact with trkB. Exercise also improves neural function by increasing neurotrophic factors. However, expression profiles of NT-4 in the brain during exercise are unknown. Here, we assessed the expressions of NT-4 and its receptor, trkB, following cerebral ischemia and hypothesized that exercise changes the expressions of NT-4 and trkB. Results showed that in a permanent middle cerebral artery occlusion rat model, ischemia decreased NT-4 and trkB expression. Immunohistochemistry showed their immunoreactivities around the region of the ischemic area. Treadmill exercise changed the expression of NT-4, which increased in the contralateral hemisphere in rats with ischemic injury. TrkB also showed similar patterns to its neurotophins. The change in NT-4 suggested that exercise might have primed NT4 production so that further injury causes slightly greater increases in NT4 compared with non-exercise controls.

• Authors: Jin-Young Chung, Min-Wook Kim, Moon-Suk Bang, Manho Kim
• Journal: PloS one (PLoS One) Vol. 8 Issue 3 Pg. e52461 ( 2013) ISSN: 1932-6203 [Electronic] United States
• PMID: 23526925 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Nerve Growth Factors
• Receptor, trkB
• neurotrophin 4

Topics

• Animals
• Brain (metabolism)
• Brain Ischemia (metabolism)
• Immunohistochemistry
• Infarction, Middle Cerebral Artery (metabolism)
• Male
• Molecular Weight
• Nerve Growth Factors (chemistry, metabolism)
• Physical Exertion (physiology)
• Rats
• Rats, Sprague-Dawley
• Receptor, trkB (chemistry, metabolism)