Abstract | OBJECTIVE:
Obesity is associated with enhanced reactive oxygen species (ROS) accumulation in adipose tissue. However, a causal role for ROS in adipose tissue expansion after high fat feeding is not established. The aim of this study is to investigate the effect of the cell permeable superoxide dismutase mimetic and peroxynitrite scavenger Mn(III)tetrakis(4-benzoic acid)porphyrin chloride ( MnTBAP) on adipose tissue expansion and remodeling in response to high fat diet (HFD) in mice. DESIGN AND METHODS: Male C57BL/6j mice were fed normal chow or high fat diet (HFD) and treated with saline or MnTBAP for 5 weeks. The effects of MnTBAP on body weights, whole body energy expenditure, adipose tissue morphology, and gene expression were determined. RESULTS: CONCLUSIONS: Taken together, these data suggest a causal role for ROS in the development of diet-induced visceral adiposity but not in the development of insulin resistance and type 2 diabetes.
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Authors | Karla M Pires, Olesya Ilkun, Marina Valente, Sihem Boudina |
Journal | Obesity (Silver Spring, Md.)
(Obesity (Silver Spring))
Vol. 22
Issue 1
Pg. 178-87
(Jan 2014)
ISSN: 1930-739X [Electronic] United States |
PMID | 23526686
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 The Obesity Society. |
Chemical References |
- Metalloporphyrins
- Reactive Oxygen Species
- manganese(III)-tetrakis(4-benzoic acid)porphyrin
- Peroxynitrous Acid
- Superoxide Dismutase
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Topics |
- Adipocytes
(drug effects, metabolism)
- Adipogenesis
(drug effects)
- Adipose Tissue
(drug effects, metabolism)
- Adiposity
(drug effects)
- Animals
- Biomimetics
- Diabetes Mellitus
(metabolism)
- Diet, High-Fat
(adverse effects)
- Inflammation
(drug therapy)
- Insulin Resistance
(physiology)
- Male
- Metalloporphyrins
(pharmacology)
- Mice
- Mice, Inbred C57BL
- Obesity
(drug therapy)
- Peroxynitrous Acid
(metabolism)
- Reactive Oxygen Species
(metabolism)
- Superoxide Dismutase
(metabolism)
- Weight Gain
(drug effects)
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